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Do Maternal Microbes Shape Newborn Oral Microbes?

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Abstract

Strong evidence suggests that the early composition of the oral microbiota of neonates plays an important role for the postnatal development of the oral health or immune system. However, the relationship between the maternal microbiome and the initial neonatal microbiome remains unclear. In this study, 25 pregnant women and their neonates were recruited, and the samples were collected from the maternal oral cavity, amniotic fluid, placenta and neonatal oral cavity. High-throughput sequencing of 16S rRNA was performed using the Illumina MiSeq platform to analyze the correlation with microbial community structure between the maternal and the neonatal oral cavity. The results indicated that the number of shared OTUs was up to 635 in four groups. The PCoA showed that there were certain similarities in the microbial community structure of the four groups. The dominant bacterial genera of the shared OTUs were consistent with human oral microbes, including Streptococcus, Fusobacterium and Prevotella. The results showed that there might be a correlation between the maternal and neonatal oral microbiome, through the amniotic fluid and placenta.

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Acknowledgements

This study was supported financially by the Area Fund Projects of the Chinese National Natural Science Fund (31560159 and 31360124/C0309), Nature Science Foundation of Gansu Province (17JR5RA217), the Science and Technology Support Project in Gansu Province (17JR5RA274 and 144WCGA167), and the Key Colleges and Universities Focus on Nurturing Project (31920180017, 31920180128). This study was fully sponsored by Gansu genenbio-yes Biotechnology Cd., Ltd and Gansu MeiTa Biomedicine Co., Ltd. The funders played no role in the study design, data collection and interpretation or in the decision to submit the work for publication.

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Author notes

  1. Shengrong Wu and Fei Yu have contributed equally to this work.

Authors and Affiliations

  1. Department of Prosthodontics, School of Stomatology, Lanzhou University, No. 199 Donggang Xi Lu, Lanzhou, 730000, Gansu Province, China

    Shengrong Wu, Fei Yu, Liya Ma & Xiangyi He

  2. Dental Department, Affiliated Hospital of Qinghai University, Xining, China

    Shengrong Wu

  3. Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China

    Youhong Zhao

  4. Department of Prosthodontics, Key Laboratory of Oral Diseases of Gansu Province, Key Laboratory of Stomatology of State Ethnic Affairs Commission, Northwest University for Nationalities, 1 Northwest Village, Lanzhou, Gansu Province, China

    Xin Zheng, Zhiqiang Li & Jianye Zhou

  5. Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China

    Xiaodong Li

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  1. Shengrong Wu
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Correspondence to Xiangyi He or Jianye Zhou.

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The authors declare that no conflict of interest exists in the study.

Informed Consent and Ethical Approval

Informed consent forms were signed by all participants included the mothers have provided the informed consent for their neonates in the study. All procedures performed in studies involving human participants met the ethical standards of the Ethics Committee of the School of Stomatology Lanzhou University (LZUE-201700012) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Wu, S., Yu, F., Ma, L. et al. Do Maternal Microbes Shape Newborn Oral Microbes?. Indian J Microbiol 61, 16–23 (2021). https://doi.org/10.1007/s12088-020-00901-7

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  • DOI: https://doi.org/10.1007/s12088-020-00901-7

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