Abstract
Multidisciplinary care (MDC) has been the most recommended approach for symptom management in amyotrophic lateral sclerosis (ALS) but there is conflicting evidence about its effectiveness on survival and quality of life (QoL) of ALS patients. We conducted a systematic review to determine the effects of multidisciplinary care compared to general neurological care in survival and quality of life of ALS patients. A comprehensive literature search using Scopus, MEDLINE-PubMed, Cochrane, Web of Science, PEDro, and Science Direct was undertaken. Studies related to multidisciplinary care or general neurological care in ALS patients that assessed survival and quality of life and were published in the period up to and including January 2020 were included. A total of 1192 studies were initially identified, but only 6 were included. All studies that investigated survival showed and advantage of MDC over NC, and this benefit was even greater for bulbar onset patients. A meta-analysis was performed and showed a mean difference of 141.67 (CI 95%, 61.48 to 221.86), indicating that patients who received MDC had longer survival than those who underwent NC (p = 0.0005). Concerning QoL, only one study found better mental health scores related to QoL for patients under MDC. Multidisciplinary care is more effective than general neurology care at improving survival of patients with ALS, but only improves mental health outcomes related to quality of life of these patients.
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Filipe Emanuel Oliveira de Almeida contributed to the study conception and design. Literature search and data analysis were performed by Filipe Emanuel Oliveira de Almeida, Anne Kelly do Carmo Santana, and Fernanda Oliveira de Carvalho. The first draft of the manuscript was written by Filipe Emanuel Oliveira de Almeida and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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de Almeida, F.E.O., do Carmo Santana, A.K. & de Carvalho, F.O. Multidisciplinary care in Amyotrophic Lateral Sclerosis: a systematic review and meta-analysis. Neurol Sci 42, 911–923 (2021). https://doi.org/10.1007/s10072-020-05011-2
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DOI: https://doi.org/10.1007/s10072-020-05011-2