A highly efficient and green approach for the synthesis of pyrimido[4,5-b]quinolines using N,N-diethyl-N-sulfoethanaminium chloride

Abdolkarim Zare; Manije Dianat

doi:10.1515/znb-2020-0098

Published by De Gruyter January 11, 2021

A highly efficient and green approach for the synthesis of pyrimido[4,5-b]quinolines using N,N-diethyl-N-sulfoethanaminium chloride

Abdolkarim Zare and Manije Dianat

From the journal Zeitschrift für Naturforschung B

https://doi.org/10.1515/znb-2020-0098

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Abstract

A highly efficient and green protocol for the synthesis of pyrimido[4,5-b]quinolines has been described. The one-pot multicomponent reaction of dimedone with arylaldehydes and 6-amino-1,3-dimethyluracil in the presence of N,N-diethyl-N-sulfoethanaminium chloride ([Et₃N–SO₃H][Cl]) as an ionic liquid (IL) catalyst under solvent-free conditions afforded the mentioned compounds in high yields and short reaction times. Our protocol is superior to many of the reported protocols in terms of two or more of these factors: the reaction times, yields, conditions (solvent-free versus usage of organic solvents), temperature and catalyst amount.

Keywords: 6-amino-1,3-dimethyluracil; acidic ionic liquid; multi-component reaction; N,N-diethyl-N-sulfoethanaminium chloride ([Et3N–SO3H][Cl]); pyrimido[4,5-b]quinoline; solvent-free

Corresponding author: Abdolkarim Zare, Department of Chemistry, Payame Noor University, P. O. Box 19395‐3697, Tehran, I. R. Iran, E-mail: abdolkarimzare@pnu.ac.ir

Funding source: Research Council of Payame Noor University

Acknowledgment

The authors acknowledge Research Council of Payame Noor University for the support of this work.

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: This work was supported by Research Council of Payame Noor University.
Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2020-05-26

Accepted: 2020-10-05

Published Online: 2021-01-11

Published in Print: 2021-02-23

A highly efficient and green approach for the synthesis of pyrimido[4,5-b]quinolines using N,N-diethyl-N-sulfoethanaminium chloride

Abstract

Acknowledgment

References

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