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Optimization of the Process for Producing 5-Nitro-2-Acetylaminobenzimidazole and its Bactericidal and Fungicidal Activity

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Pharmaceutical Chemistry Journal Aims and scope

The main factors affecting production of 5-nitro-2-acetylaminobenzimidazole were identified. The process was optimized using mathematical experiment planning. A mathematical model was compiled. A regression equation was calculated. The optimum process conditions including the temperature, duration, and quantitative ratio of starting compounds were found. The bactericidal and fungicidal activities of 5-nitro-2-acetylaminobenzimidazole against Xanthomonas malvacearum culture were studied under laboratory conditions.

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Authors and Affiliations

  1. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan, 100170

    S. S. Saidov

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  1. S. S. Saidov
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Correspondence to S. S. Saidov.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 10, pp. 33 – 36, October, 2020.

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Saidov, S.S. Optimization of the Process for Producing 5-Nitro-2-Acetylaminobenzimidazole and its Bactericidal and Fungicidal Activity. Pharm Chem J 54, 1015–1018 (2021). https://doi.org/10.1007/s11094-021-02313-3

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  • DOI: https://doi.org/10.1007/s11094-021-02313-3

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