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Preparation and In Vitro/Vivo Evaluation of New Celecoxib Solid Dispersions with Co-Carrier Containing Aerosil and Poloxamer 188

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Pharmaceutical Chemistry Journal Aims and scope

Solid dispersions (SDs) containing co-carrier were developed to improve in vitro dissolution and in vivo pharmacokinetics of celecoxib (CXB). Various polymers, including PVP K30, PEG4000, PEG6000, Poloxamer 188, Eudragit E100 and colloidal SiO2, were studied in the preparation of CXB-containing SDs. Poloxamer 188 and Aerosil stood out in preliminary characterization. Further study was focused on the selection and characterization of optimum ratio of CXB and polymer in solid dispersions (CXB-Poloxamer 188-Aerosil, 1:5:1). Results exhibited remarkable enhancement of both the dissolution and bioavailability of CXB which retained an amorphous form in SD samples.

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Funding

This work was supported by Project 21606203 of the Natural Science Foundation of China.

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Authors and Affiliations

  1. National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, 310014, P. R. China

    Xiangjun Shi, Zejie Ding, Jiayin Bao & Chao Wang

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  1. Xiangjun Shi
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  2. Zejie Ding
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  3. Jiayin Bao
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  4. Chao Wang
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Correspondence to Xiangjun Shi.

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Shi, X., Ding, Z., Bao, J. et al. Preparation and In Vitro/Vivo Evaluation of New Celecoxib Solid Dispersions with Co-Carrier Containing Aerosil and Poloxamer 188. Pharm Chem J 54, 1033–1039 (2021). https://doi.org/10.1007/s11094-021-02316-0

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  • DOI: https://doi.org/10.1007/s11094-021-02316-0

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