Skip to main content
SpringerLink
Log in

Neuropsychological Assessment and Screening in Heart Failure: a Meta-Analysis and Systematic Review

  • Review
  • Published:
Neuropsychology Review Aims and scope Submit manuscript

Abstract

A variety of neuropsychological changes secondary to heart failure have been documented in the literature. However, what remains unclear are which neuropsychological abilities are the most impacted by heart failure and what tests have the sensitivity to measure that impact. Eight databases were searched for articles that examined the neuropsychological functioning of patients with heart failure. Some of the inclusion criteria were articles had to have a heart failure group with a demographically comparable control group and standardized neuropsychological testing. Exclusion criteria included articles with a heart failure group with any other type of major organ failure, or comparisons that were between different classes of heart failure rather than between a heart failure and non-heart failure group. A total of 33 articles met the inclusion criteria (total heart failure sample n = 8900) and provided effect size data for 20 neuropsychological domains. All observed domain-level differences between heart failure and non-heart failure groups were statistically significant, except for simple motor functioning and confrontation naming. The greatest differences in performance were in executive functioning, global cognition, complex psychomotor speed, and verbal memory. The highest effect sizes came from Trail-Making Test-Part B, CAMCOG, Symbol Digit Modality Test, and California Verbal Learning Test. The neuropsychological patterns of heart failure suggested diffuse cognitive involvement, with higher-level processes being most affected. It is important to track neurocognition in this clinical population since neuropsychological impairment is prevalent, and screening measures appear to be reliable. Such screening and further assessment would inform future medical treatment and may improve patient care management.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Adebayo, P. B., Akintunde, A. A., Audu, M. B., Ayodele, O. E., Akinyemi, R. O., & Opadijo, O. G. (2016). Profile and determinants of neurocognitive dysfunction in a sample of adult Nigerians with heart failure. Journal of Cardiovascular Nursing, 31(6), 535–544. https://doi.org/10.1097/jcn.0000000000000289

    Article  Google Scholar 

  • Agarwal, K. S., Kazim, R., Xu, J., Borson, S., & Taffet, G. E. (2016). Unrecognized cognitive impairment and its effect on heart failure readmissions of elderly adults. Journal of American Geriatric Society, 64(11), 2296–2301. https://doi.org/10.1111/jgs.14471

    Article  Google Scholar 

  • Alagiakrishnan, K., Mah, D., Dyck, J. R., Senthilselvan, A., & Ezekowitz, J. (2017). Comparison of two commonly used clinical cognitive screening tests to diagnose mild cognitive impairment in heart failure with the golden standard European consortium criteria. International Journal of Cardiology, 228, 558–562. https://doi.org/10.1016/j.ijcard.2016.11.193

    Article  PubMed  Google Scholar 

  • Aldrugh, S., Sardana, M., Henninger, N., Saczynski, J. S., & McManus, D. D. (2017). Atrial fibrillation, cognition and dementia: A review. Journal of Cardiovascular Electrophysiology, 28(8), 958–965. https://doi.org/10.1111/jce.13261

    Article  PubMed  PubMed Central  Google Scholar 

  • Almeida, O. P., Beer, C., Lautenschlager, N. T., Arnolda, L., Alfonso, H., & Flicker, L. (2012). Two-year course of cognitive function and mood in adults with congestive heart failure and coronary artery disease: The heart-mind study. International Psychogeriatrics, 24(1), 38–47. https://doi.org/10.1017/s1041610211001657

    Article  PubMed  Google Scholar 

  • Almeida, O. P., & Tamai, S. (2001). Congestive heart failure and cognitive functioning amongst older adults. Arquivos de Neuro-Psiquiatria, 59(2B), 324–329.

    Article  CAS  Google Scholar 

  • Alosco, M. L., Gunstad, J., Jerskey, B. A., Clark, U. S., Hassenstab, J. J., Xu, X., & Sweet, L. H. (2013). Left atrial size is independently associated with cognitive function. International Journal of Neuroscience, 123(8), 544–552. https://doi.org/10.3109/00207454.2013.774396

    Article  Google Scholar 

  • Alosco, M. L., Spitznagel, M. B., Cohen, R., Raz, N., Sweet, L. H., Josephson, R., & Gunstad, J. (2014). Reduced cerebral perfusion predicts greater depressive symptoms and cognitive dysfunction at a 1-year follow-up in patients with heart failure. International Journal of Geriatric Psychiatry, 29(4), 428–436. https://doi.org/10.1002/gps.4023

    Article  PubMed  Google Scholar 

  • Alosco, M. L., Spitznagel, M. B., Sweet, L. H., Josephson, R., Hughes, J., & Gunstad, J. (2015). Atrial fibrillation exacerbates cognitive dysfunction and cerebral perfusion in heart failure. Pacing and Clinical Electrophysiology, 38(2), 178–186. https://doi.org/10.1111/pace.12543

    Article  PubMed  Google Scholar 

  • Alves, T. C., Rays, J., Telles, R. M., Junior, R. F., Wajngarten, M., Romano, B. W., & Busatto, G. F. (2007). Effects of antidepressant treatment on cognitive performance in elderly subjects with heart failure and comorbid major depression: An exploratory study. Psychosomatics, 48(1), 22–30. https://doi.org/10.1176/appi.psy.48.1.22

    Article  PubMed  Google Scholar 

  • Alwerdt, J., Edwards, J. D., Athilingam, P., O'Connor, M. L., & Valdes, E. G. (2013). Longitudinal differences in cognitive functioning among older adults with and without heart failure. Journal of Aging and Health, 25(8), 1358–1377. https://doi.org/10.1177/0898264313505111

    Article  PubMed  Google Scholar 

  • Athilingam, P., D'Aoust, R. F., Miller, L., & Chen, L. (2013). Cognitive profile in persons with systolic and diastolic heart failure. Congestive Heart Failure, 19(1), 44–50. https://doi.org/10.1111/chf.12001

    Article  PubMed  Google Scholar 

  • Beer, C., Ebenezer, E., Fenner, S., Lautenschlager, N. T., Arnolda, L., Flicker, L., & Almeida, O. P. (2009). Contributors to cognitive impairment in congestive heart failure: A pilot case-control study. International Medical Journal, 39(9), 600–605. https://doi.org/10.1111/j.1445-5994.2008.01790.x

    Article  CAS  Google Scholar 

  • Bhat, G., Yost, G., & Mahoney, E. (2015). Cognitive function and left ventricular assist device implantation. The Journal of Heart and Lung Transplantation, 24(11), 1398–1405. https://doi.org/10.1016/j.healun.2015.05.015

    Article  Google Scholar 

  • Borenstein, M., Hedges, L. V., Higgins, J. P., & Rothstein, H. R. (2011). Introduction to meta-analysis. John Wiley & Son.

  • Borenstein, M., Higgins, J. P., Hedges, L. V., & Rothstein, H. R. (2017). Basics of meta-analysis: I2 is not an absolute measure of heterogeneity. Research Synthesis Methods, 8(1), 5–18.

    Article  Google Scholar 

  • Caruso, P., Signori, R., & Moretti, R. (2019). Small vessel disease to subcortical dementia: A dynamic model, which interfaces aging, cholinergic dysregulation and the neurovascular unit. Vascular Health and Risk Management, 15, 259–281. https://doi.org/10.2147/VHRM.S190470

    Article  PubMed  PubMed Central  Google Scholar 

  • Chou, C. C., Pressler, S. J., & Giordani, B. (2014). Predictors of memory performance among Taiwanese postmenopausal women with heart failure. Journal of Cardiac Failure, 20(9), 679–688. https://doi.org/10.1016/j.cardfail.2014.06.002

    Article  PubMed  Google Scholar 

  • Cohen, J. (1992). A power primer. Psychological Bulletin, 112(1), 155–159. https://doi.org/10.1037//0033-2909.112.1.155

  • de la Torre, J. C. (2012). Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia. Cardiovascular Psychiatry and Neurology, 2012, 1–15.

    Article  Google Scholar 

  • Festa, J. R., Jia, X., Cheung, K., Marchidann, A., Schmidt, M., Shapiro, P. A., & Lazar, R. M. (2011). Association of low ejection fraction with impaired verbal memory in older patients with heart failure. Archives of Neurology, 68(8), 1021–1026. https://doi.org/10.1001/archneurol.2011.163

  • Frey, A., Sell, R., Homola, G. A., Malsch, C., Kraft, P., Gunreben, I., & Stoll, G. (2018). Cognitive deficits and related brain lesions in patients with chronic heart failure. Journal of American College of Cardiology: Heart Failure, 6(7), 583–592. https://doi.org/10.1016/j.jchf.2018.03.010

    Article  Google Scholar 

  • Gates, N. J., & March, E. G. (2016). A neuropsychologist’s guide to undertaking a systematic review for publication: Making the most of PRISMA guidelines. Neuropsychology Review, 26(2), 109–120.

    Article  Google Scholar 

  • Goodall, J., Fisher, C., Hetrick, S., Phillips, L., Parrish, E. M., & Allott, K. (2018). Neurocognitive functioning in depressed young people: A systematic review and meta-analysis. Neuropsychology Review, 28(2), 216–231. https://doi.org/10.1007/s11065-018-9373-9

    Article  PubMed  Google Scholar 

  • Grimm, G. (1996). Congestive heart failure/ventricular hypertrophy/ heart transplantation may affect improvement of cognitive brain function after successful cardiac transplantation.

  • Grubb, N. R., Simpson, C., & Fox, K. A. (2000). Memory function in patients with stable, moderate to severe cardiac failure. American Heart Journal, 140(1), E1–E5.

    Article  CAS  Google Scholar 

  • Habota, T., McLennan, S. N., Cameron, J., Henry, J. D., Ski, C. F., Thompson, D. R., & Rendell, P. G. (2015). Prospective memory impairment in chronic heart failure. Journal of the International Neuropsychological Society, 21(3), 183–192. https://doi.org/10.1017/s1355617715000119

    Article  PubMed  Google Scholar 

  • Hajduk, A. M., Kiefe, C. I., Person, S. D., Gore, J. G., & Saczynski, J. S. (2013). Cognitive change in heart failure: A systematic review. Circulation. Cardiovascular Quality and Outcomes, 6(4), 1–20. https://doi.org/10.1161/circoutcomes.113.000121

    Article  Google Scholar 

  • Hall, M. G., Hauson, A. O., Wollman, S. C., Allen, K. E., Connors, E. J., Stern, M. J., & Grant, I. (2018). Neuropsychological comparisons of cocaine versus methamphetamine users: A research synthesis and meta-analysis. The American Journal of Drug and Alcohol Abuse, 44(3), 277–293. https://doi.org/10.1080/00952990.2017.1355919

    Article  PubMed  Google Scholar 

  • Hammond, C. A., Blades, N. J., Chaudhry, S. I., Dodson, J. A., Longstreth Jr., W. T., Heckbert, S. R., … Gardin, J. M. (2018). Long-term cognitive decline after newly diagnosed heart failure: Longitudinal analysis in the CHS (Cardiovascular Health Study). Circulation: Heart Failure, 11(3), e004476. https://doi.org/10.1161/circheartfailure.117.004476

  • Harkness, K., Heckman, G. A., Akhtar-Danesh, N., Demers, C., Gunn, E., & McKelvie, R. S. (2014). Cognitive function and self-care management in older patients with heart failure. European Journal of Cardiovascular Nursing, 13(3), 277–284. https://doi.org/10.1177/1474515113492603

  • Higgins, J. P., & Green, S. (Eds.). (2011). Cochrane handbook for systematic reviews of interventions (Vol. 4). John Wiley & Sons.

  • Hjelm, C., Dahl, A., Brostrom, A., Martensson, J., Johansson, B., & Stromberg, A. (2012). The influence of heart failure on longitudinal changes in cognition among individuals 80 years of age and older. Journal of Clinical Nursing, 21(7–8), 994–1003. https://doi.org/10.1111/j.1365-2702.2011.03817.x

    Article  PubMed  Google Scholar 

  • Hoth, K. F., Poppas, A., Moser, D. J., Paul, R. H., & Cohen, R. A. (2008). Cardiac dysfunction and cognition in older adults with heart failure. Cognitive and Behavioral Neurology, 21(2), 65–72. https://doi.org/10.1097/WNN.0b013e3181799dc8

    Article  PubMed  Google Scholar 

  • Jesus, P. A., Vieira-de-Melo, R. M., Reis, F. J., Viana, L. C., Lacerda, A., Dias, J. S., & Oliveira-Filho, J. (2006). Cognitive dysfunction in congestive heart failure: Transcranial Doppler evidence of microembolic etiology. Arq Neuropsiquiatr, 64(2a), 207–210.

    Article  Google Scholar 

  • Jung, M., Jonides, J., Northouse, L., Berman, M. G., Koelling, T. M., & Pressler, S. J. (2016). Randomized crossover study of the natural restorative environment intervention to improve attention and mood in heart failure. Journal of Cardiovascular Nursing, 32(5), 464–479. https://doi.org/10.1097/jcn.0000000000000368

    Article  Google Scholar 

  • Kemp, C. D., & Conte, J. V. (2012). The pathophysiology of heart failure. Cardiovascular Pathology, 2(5), 365–271. https://doi.org/10.1016/j.carpath.2011.11.007

    Article  CAS  Google Scholar 

  • Kim, J., Shin, M. S., Hwang, S. Y., Park, E., Lim, Y. H., Shim, J. L., & An, M. (2018). Memory loss and decreased executive function are associated with limited functional capacity in patients with heart failure compared to patients with other medical conditions. Heart & Lung, 47(1), 61–67. https://doi.org/10.1016/j.hrtlng.2017.09.005

    Article  Google Scholar 

  • Kindermann, I., Fischer, D., Karbach, J., Link, A., Walenta, K., Barth, C., & Böhm, M. (2012). Cognitive function in patients with decompensated heart failure: The cognitive impairment in heart failure (CogImpair-HF) study. European Journal of Heart Failure, 14(4), 404–413. https://doi.org/10.1093/eurjhf/hfs015

    Article  CAS  PubMed  Google Scholar 

  • Komori, T., Eguchi, K., Saito, T., Nishimura, Y., Hoshide, S., & Kario, K. (2016). Riser blood pressure pattern is associated with mild cognitive impairment in heart failure patients. American Journal of Hypertension, 29(2), 194–201. https://doi.org/10.1093/ajh/hpv086

  • Kumar, R., Yadav, S. K., Palomares, J. A., Park, B., Joshi, S. H., Ogren, J. A., & Woo, M. A. (2015). Reduced regional brain cortical thickness in patients with heart failure. PLoS One, 10(5), e0126595. https://doi.org/10.1371/journal.pone.0126595

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kure, C. E., Rosenfeldt, F. L., Scholey, A. B., Pipingas, A., Kaye, D. M., Bergin, P. J., & Stough, C. (2016). Relationships among cognitive function and cerebral blood flow, oxidative stress, and inflammation in older heart failure patients. Journal of Cardiac Failure, 22(7), 548–559. https://doi.org/10.1016/j.cardfail.2016.03.006

    Article  CAS  PubMed  Google Scholar 

  • Lavery, L., Bilt, J. V., Chang, C.-C. H., Saxton, J. A., & Ganguli, M. (2007). The association between congestive heart failure and cognitive performance in a primary care population of elderly adults: The Steel Valley Seniors Survey. International Psychogeriatrics, 19(2), 215–225. https://doi.org/10.1017/S1041610206003449

  • Lezak, M. D., Howieson, D. B., Bigler, E. D., & Tranel, D. (2012). Neuropsychological assessment (5th ed.). New York, NY, US: Oxford University Press.

    Google Scholar 

  • Mapelli, D., Cavazzana, A., Cavalli, C., Bottio, T., Tarzia, V., Gerosa, G., & Volpe, B. R. (2014). Clinical psychological and neuropsychological issues with left ventricular assist devices (LVADs). Annals of Cardiothoracic Surgery, 3(5), 480–489.

    PubMed  PubMed Central  Google Scholar 

  • Meguro, T., Meguro, Y., & Kunieda, T. (2017). Atrophy of the parahippocampal gyrus is prominent in heart failure patients without dementia. ESC Heart Fail, 4(4), 632–640. https://doi.org/10.1002/ehf2.12192

    Article  PubMed  PubMed Central  Google Scholar 

  • Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., & Stewart, L. A. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews, 4(1), 1. https://doi.org/10.1186/2046-4053-4-1

    Article  PubMed  PubMed Central  Google Scholar 

  • Moon, C., Yoon, J. Y., & Bratzke, L. C. (2016). The role of heart failure, daytime sleepiness, and disturbed sleep on cognition. Western Journal of Nursing Research, 9(4), 473–491. https://doi.org/10.1177/0193945916675587

    Article  Google Scholar 

  • Moryś, J. M., Pąchalska, M., Bellwon, J., & Gruchała, M. (2016). Cognitive impairment, symptoms of depression, and health-related quality of life in patients with severe stable heart failure. International Journal of Clinical and Health Psychology, 16(3), 230–238. https://doi.org/10.1016/j.ijchp.2016.03.002

    Article  PubMed  PubMed Central  Google Scholar 

  • Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., & Turner, M. B. (2016). Heart disease and stroke statistics-2016 update: A report from the American Heart Association. Circulation, 133, e38–e360. https://doi.org/10.1161/CIR.0000000000000350

  • National Heart, Lung, and Blood Institute. (2014). Quality assessment tool for observational cohort and cross-sectional studies. Bethesda: National Institutes of Health, Department of Health and Human Services.

    Google Scholar 

  • Niizeki, T., Iwayama, T., Ikeno, E., & Watanabe, M. (2019). Prognostic importance of hippocampal atrophy in patients with chronic heart failure. The American Journal of Cardiology, 123(7), 1109–1113. https://doi.org/10.1016/j.amjcard.2018.12.035

  • Nikendei, C., Schäfer, H., Weisbrod, M., Huber, J., Geis, N., Katus, H. A., & Schultz, J.-H. (2016). The effects of mitral valve repair on memory performance, executive function, and psychological measures in patients with heart failure. Psychosomatic Medicine, 78(4), 432–442. https://doi.org/10.1097/PSY.0000000000000284

    Article  PubMed  Google Scholar 

  • Nordlund, A., Berggren, J., Holmstrom, A., Fu, M., & Wallin, A. (2015). Frequent mild cognitive deficits in several functional domains in elderly patients with heart failure without known cognitive disorders. Journal of Cardiac Failure, 21(9), 702–707. https://doi.org/10.1016/j.cardfail.2015.04.006

    Article  PubMed  Google Scholar 

  • Parsons, M. W., Hammeke, T. A., & Snyder, P. J. (2014). Clinical neuropsychology: A pocket handbook for assessment. American Psychological Association.

  • Petrucci, R. J., Rogers, J. G., Blue, L., Gallagher, C., Russell, S. D., Dordunoo, D., & Slaughter, M. S. (2012). Neurocognitive function in destination therapy patients receiving continuous-flow vs pulsatile-flow left ventricular assist device support. The Journal of Heart and Lung Transplantation, 31(1), 27–36. https://doi.org/10.1016/healun.2011.10.012

    Article  PubMed  Google Scholar 

  • Prado, C. E., Watt, S., & Crowe, S. F. (2018). A meta-analysis of the effects of antidepressants on cognitive functioning in depressed and non-depressed samples. Neuropsychology Review, 28(1), 32–72. https://doi.org/10.1007/s11065-018-9369-5

    Article  PubMed  Google Scholar 

  • Pressler, S. J., Subramanian, U., Kareken, D., Perkins, S. M., Gradus-Pizlo, I., Sauve, M. J., & Shaw, R. M. (2010). Cognitive deficits in chronic heart failure. Nursing Research, 59(2), 127–139. https://doi.org/10.1097/NNR.0b013e3181d1a747

    Article  PubMed  PubMed Central  Google Scholar 

  • Putzke, J. D., Williams, M. A., Daniel, F. J., Bourge, R. C., & Boll, T. J. (2000). Activities of daily living among heart transplant candidates: Neuropsychological and cardiac function predictors. Journal of Heart and Lung Transportation, 19(10), 995–1006.

    Article  CAS  Google Scholar 

  • Qiu, C., Winblad, B., Marengoni, A., Klarin, I., Fastbom, J., & Fratiglioni, L. (2006). Heart failure and risk of dementia and Alzheimer disease. Archives of Internal Medicine, 166(9), 1003. https://doi.org/10.1001/archinte.166.9.1003

    Article  PubMed  Google Scholar 

  • Roy, B., Woo, M. A., Wang, D. J. J., Fonarow, G. C., Harper, R. M., & Kumar, R. (2017). Reduced regional cerebral blood flow in patients with heart failure. European Journal of Heart Failure, 19(10), 1294–1302. https://doi.org/10.1002/ejhf.874

    Article  PubMed  PubMed Central  Google Scholar 

  • Schmidt, R., Fazekas, F., Offenbacher, H., Dusleag, J., & Lechner, H. (1991). Brain magnetic resonance imaging and neuropsychologic evaluation of patients with idiopathic dilated cardiomyopathy. Stroke, 22(2), 195–199.

    Article  CAS  Google Scholar 

  • Siachos, T., Vanbakel, A., Feldman, D. S., Uber, W., Simpson, K. N., & Pereira, N. L. (2005). Silent strokes in patients with heart failure. Journal of Cardiac Failure, 11(7), 485–489. https://doi.org/10.1016/j.cardfail.2005.04.004

  • Stanek, K. M., Gunstad, J., Paul, R. H., Poppas, A., Jefferson, A. L., Sweet, L. H., & Cohen, R. A. (2009). Longitudinal cognitive performance in older adults with cardiovascular disease: Evidence for improvement in heart failure. Journal of Cardiovascular Nursing, 24(3), 192–197. https://doi.org/10.1097/JCN.0b013e31819b54de

    Article  Google Scholar 

  • Staniforth, A. D., Kinnear, W. J., & Cowley, A. J. (2001). Cognitive impairment in heart failure with Cheyne-stokes respiration. Heart, 85(1), 18–22.

    Article  CAS  Google Scholar 

  • Stephan, R. A., Alhassoon, O. M., Allen, K. E., Wollman, S. C., Hall, M., Thomas, W. J., & Dalenberg, C. J. (2017). Meta-analyses of clinical neuropsychological tests of executive dysfunction and impulsivity in alcohol use disorder. The American Journal of Drug and Alcohol Abuse, 43(1), 24–43. https://doi.org/10.1080/00952990.2016.1206113

    Article  PubMed  Google Scholar 

  • Strauss, E., Sherman, E. M. S., & Spreen, O. (2006). A compendium of neuropsychological tests: Administration, norms, and commentary (3rd ed.). New York: Oxford University Press.

    Google Scholar 

  • Suavé, M. J., Lewis, W. R., Blankenbiller, M., Rickabaugh, B., & Pressler, S. J. (2009). Cognitive impairments in chronic heart failure: A case-controlled study. Journal of Cardiac Failure, 15(1), 1–10. https://doi.org/10.1016/j.cardfail.2008.09.007

    Article  Google Scholar 

  • Suchy, Y. (2015). Executive functioning: A comprehensive guide for clinical practice. Oxford University Press.

  • Trojano, L., Antonelli Incalzi, R., Acanfora, D., Picone, C., Mecocci, P., & Rengo, F. (2003). Cognitive impairment: A key feature of congestive heart failure in the elderly. Journal of Neurology, 250(12), 1456–1463. https://doi.org/10.1007/s00415-003-0249-3

    Article  PubMed  Google Scholar 

  • Viechtbauer, W., & Cheung, M. W. L. (2010). Outlier and influence diagnostics for meta-analysis. Research Synthesis Methods, 1(2), 112–125. https://doi.org/10.1002/jrsm.11

    Article  PubMed  Google Scholar 

  • Vogels, R. L., Oosterman, J. M., van Harten, B., Scheltens, P., van der Flier, W. M., Schroeder-Tanka, J. M., & Weinstein, H. C. (2007). Profile of cognitive impairment in chronic heart failure. Journal of American Geriatrics Society, 55(11), 1764–1770. https://doi.org/10.1111/j.1532-5415.2007.01395.x

    Article  Google Scholar 

  • Weintraub, S., Wicklund, A. H., & Salmon, D. P. (2012). The neuropsychological profile of Alzheimer disease. Cold Spring Harbor Perspectives in Medicine, 2(4), a006171. https://doi.org/10.1101/cshperspect.a006171

    Article  PubMed  PubMed Central  Google Scholar 

  • Wollman, S. C., Hauson, A. O., Hall, M. G., Connors, E. J., Allen, K. E., Stern, M. J., & Flora-Tostado, C. (2019). Neuropsychological functioning in opioid use disorder: A research synthesis and meta-analysis. The American Journal of Drug and Alcohol Abuse, 45(1), 11–25. https://doi.org/10.1080/00952990.2018.1517262

    Article  PubMed  Google Scholar 

  • Woo, M. A., Yadav, S. K., Macey, P. M., Fonarow, G. C., Harper, R. M., & Kumar, R. (2014). Brain metabolites in autonomic regulatory insular sites in heart failure. Journal of the Neurological Sciences, 346(1–2), 271–275. https://doi.org/10.1016/j.jns.2014.09.006

  • Woo, M. A., Ogren, J. A., Abouzeid, C. M., Macey, P. M., Sairafian, K. G., Saharan, P. S., & Kumar, R. (2015a). Regional hippocampal damage in heart failure. European Journal of Heart Failure, 17(5), 494–500. https://doi.org/10.1002/ejhf.241

  • Woo, M. A., Palomares, J. A., Macey, P. M., Fonarow, G. C., Harper, R. M., & Kumar, R. (2015b). Global and regional brain mean diffusivity changes in patients with heart failure. Journal of Neuroscience Research, 93(4), 678–685. https://doi.org/10.1002/jnr.23525

  • Yohannes, A. M., Chen, W., Moga, A. M., Leroir, I., & Connolly, M. J. (2017). Cognitive impairment in chronic obstructive pulmonary disease and chronic heart failure: A systematic review and meta-analysis of observational studies. Journal of the American Medical Directors Association, 11(5), S1525–S8610. https://doi.org/10.1016/j.jamda.2017.01.014

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. California School of Professional Psychology, Clinical Psychology PhD Program, San Diego, CA, USA

    Eric J. Connors, Alexander O. Hauson, Brianna D. Barlet, Sharis Sarkissians, Nicholas P. Stelmach, Alyssa D. Walker, Natasha M. Nemanim, Scott C. Wollman, Kenneth E. Allen, Matthew G. Hall & Christopher Flora-Tostado

  2. Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School and Home Base, a Red Sox Foundation and Massachusetts General Hospital Program, Charlestown, MA, USA

    Eric J. Connors

  3. Institute of Brain Research and Integrated Neuropsychological Services (iBRAINs.org), San Diego, CA, USA

    Eric J. Connors, Alexander O. Hauson, Brianna D. Barlet, Sharis Sarkissians, Nicholas P. Stelmach, Alyssa D. Walker, Natasha M. Nemanim, Scott C. Wollman, Kenneth E. Allen, Matthew G. Hall & Christopher Flora-Tostado

  4. Department of Psychiatry, University of California San Diego, La Jolla, CA, USA

    Alexander O. Hauson

  5. Sharp HealthCare, San Diego, CA, USA

    Kristina L. Greenwood & Nicholas J. Chesher

Authors
  1. Eric J. Connors
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alexander O. Hauson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Brianna D. Barlet
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sharis Sarkissians
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Nicholas P. Stelmach
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Alyssa D. Walker
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Natasha M. Nemanim
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Kristina L. Greenwood
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Nicholas J. Chesher
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Scott C. Wollman
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Kenneth E. Allen
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Matthew G. Hall
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Christopher Flora-Tostado
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alexander O. Hauson.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

ESM 1

(DOCX 29 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Connors, E.J., Hauson, A.O., Barlet, B.D. et al. Neuropsychological Assessment and Screening in Heart Failure: a Meta-Analysis and Systematic Review. Neuropsychol Rev 31, 312–330 (2021). https://doi.org/10.1007/s11065-020-09463-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11065-020-09463-3

Keywords

Search

Navigation