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Freeze Dried Biodegradable Polycaprolactone/Chitosan/Gelatin Porous Scaffolds for Bone Substitute Applications

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Abstract

In current work, the porous 3D bone substitute scaffolds based on the chitosan, gelatin and polycaprolactone using freeze drying technique are introduced. SEM images showed that all the scaffolds had porous structures with average pore diameter size of 23–183 µm. The results of FTIR demonstrated the successful blending of scaffolds. Also, the compression test results determined that the presence of polycaprolactone effectively improved the mechanical properties of the chitosan/gelatin/polycaprolactone scaffolds, having the highest strength, i.e. 24.5 MPa and highest modulus, i.e. 3.86 MPa. The degradation behavior obtained under lysozyme/PBS solutions revealed that the chitosan/gelatin scaffold had a faster degradation rate rather than other scaffolds. MTT assay as well as cell attachment analysis confirmed the appropriate cell viability and cell adhesion on the scaffolds. Taken together, the scaffolds developed in this study may find potential application in bone substitution applications.

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Acknowledgments

The authors wish to acknowledge Esfarayen University of Technology (EUT) and Sadjad University of Technology for all supports throughout this cooperative project.

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Authors and Affiliations

  1. Department of Mechanical and Materials Engineering, Sadjad University of Technology, Mashhad, Iran

    Mahsa Haghbin & Saeed Kahrobaee

  2. Esfarayen University of Technology, Esfarayen, North Khorasan, Iran

    Javad Esmaeilzadeh

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  1. Mahsa Haghbin
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  2. Javad Esmaeilzadeh
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  3. Saeed Kahrobaee
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Correspondence to Javad Esmaeilzadeh.

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Haghbin, M., Esmaeilzadeh, J. & Kahrobaee, S. Freeze Dried Biodegradable Polycaprolactone/Chitosan/Gelatin Porous Scaffolds for Bone Substitute Applications. Macromol. Res. 28 (Suppl 1), 1232–1240 (2020). https://doi.org/10.1007/s13233-020-8170-5

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  • DOI: https://doi.org/10.1007/s13233-020-8170-5

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