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4-Iodophenylboronic Acid Stabilized Gold Cluster as a New Fluorescent Chemosensor for Saccharides Based on Excimer Emission Quenching

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Abstract

4-iodophenylboronic acid (IPBA) ligated luminescent gold cluster was synthesized by mixing an aqueous solution of IBPA and polyvinylpyrrolidone stabilized gold cluster (Au:PVP) in water at room temperature through chemisorption of iodine on gold nano surface. Transmission Electron microscopy (TEM) and matrix assisted laser desorption ionization (MALDI) analysis revealed that the size of these Au-clusters (1.4±0.2 nm) remain unchanged without any noticeable aggregation during synthesis. Owing to the formation of excimer between aryl moieties grafted over Au surface, the cluster exhibit strong emission peak at 335 nm. This luminescent gold cluster is used for sensing different saccharides in water at physiological pH through quenching of excimer emission peak. This strong excimer emission is significantly quenched in presence of saccharides through interaction with boronic acid moieties. The selectivity for different saccharides follows the order: fructose > galactose > maltose > glucose ~ ribose > sorbitol with hight affinity for fructose (KSV = 1.54 × 104 M−1) with Limit of Detection (LOD) of 100 μM.

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Data Availability

The authors declare that the data supporting the findings of this study are available in the article and in the supplementary materials.

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Funding

This work was supported by Council of Scientific & Industrial Research (CSIR, New Delhi) (Project no. 01(2873)/17/EMR-II).

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Authors and Affiliations

  1. School of Engineering and Technology, National Forensic Sciences University, Sect or-09, Gandhinagar, 382007, India

    Jaydev Thakarda, Pranav Dave, Sagar Bhowmik, Jasmin Kubavat & Prasenjit Maity

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  1. Jaydev Thakarda
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  2. Pranav Dave
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  3. Sagar Bhowmik
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  4. Jasmin Kubavat
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  5. Prasenjit Maity
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Contributions

JT, PD, SB synthesized and characterized the nanocomposite and did all the sensing studies using spectrofluoremetry, SB performed MALDI mass measurements, JK and PM conceptualized the work and wrote the paper.

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Correspondence to Jasmin Kubavat or Prasenjit Maity.

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Thakarda, J., Dave, P., Bhowmik, S. et al. 4-Iodophenylboronic Acid Stabilized Gold Cluster as a New Fluorescent Chemosensor for Saccharides Based on Excimer Emission Quenching. J Fluoresc 31, 447–454 (2021). https://doi.org/10.1007/s10895-020-02672-2

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  • DOI: https://doi.org/10.1007/s10895-020-02672-2

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