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Elevated levels of NLRP3 inflammasome in serum of patients with chronic inflammatory demyelinating polyradiculoneuropathy are associated with disease severity

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Abstract

This study aims to compare the levels of NLRP3 inflammasome and its related cytokines (IL-1β, IL-6, and IL-17), in serum and cerebrospinal fluid (CSF) of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), non-inflammatory chronic polyneuropathy, and functional neurological disorders. The results showed elevated NLRP3 inflammasome, IL-1β, IL-6, and IL-17 levels in serum but not in CSF of CIDP, compared to the other groups. Moreover, there was a positive correlation between NLRP3 inflammasome level and each cytokine. We also found a positive correlation between serum NLRP3 inflammasome level and disease severity in CIDP patients. Taken together, these results suggested that NLRP3 inflammasome could act as a potential biomarker to diagnose CIDP and assess the severity of the disease.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, China

    Zhi-Jie Zhou

  2. Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, China

    Ping Xia

Authors
  1. Zhi-Jie Zhou
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  2. Ping Xia
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Contributions

Ping Xia designed the study and collected the data. Zhi-Jie Zhou analyzed the data and drafted the manuscript. Both authors revised and approved the manuscript.

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Correspondence to Ping Xia.

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The authors declare that they have no conflict of interest.

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The study was approved by the Ethics Committee of Sir Run Run Shaw Hospital and informed consents were obtained from all patients included in the study.

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Zhou, ZJ., Xia, P. Elevated levels of NLRP3 inflammasome in serum of patients with chronic inflammatory demyelinating polyradiculoneuropathy are associated with disease severity. Neurol Sci 42, 3383–3387 (2021). https://doi.org/10.1007/s10072-020-04949-7

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  • DOI: https://doi.org/10.1007/s10072-020-04949-7

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