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Developing and Featuring Matrix Tablets by Using Gross Linseed Mucilage as a Retardant Polymer

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Abstract

Purpose

Evaluating the potential of gross Linum usitatissimum L. seed mucilage to be used as a drug release retardant. In order to do so, seeds were subjected to a simple and scalable extractive process comprising few stages, without alcohol-based precipitation. Matrix tablets based on hydrophilic polymers are one of the simplest forms of developing modified release systems.

Methods

Flaxseeds were added to distilled water at a flaxseed:water ratio of 1:13; the suspension was continuously stirred at room temperature, for 24 h. Flaxseeds were sieved and the gross linseed mucilage was freeze-dried. Subsequently, the sample was analyzed through Fourier transform infrared spectroscopy (IV-TF) at wavelength ranging from 650 to 4000 cm−1.

Results

Infrared (IR) spectroscopy analysis has suggested the presence of flaxseed mucilage polymers in the extracted product. Tablets presenting mucilage or HPMC (hydroxypropyl methylcellulose) and tablets without polymer were prepared based on the wet granulation technique. Matrix tablets presenting mucilage or HPMC have shown similar dissolution profiles, as well as similar potential in drug release control.

Conclusion

The product extracted from flaxseed under simple conditions, even without undergoing purification process, can have high technological value in the pharmaceutical industry because it has excellent potential to be used as excipient for matrix tablet manufacturing.

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Acknowledgments

The authors would like to thank the Brazilian Government Agency Coordination for the Improvement of Higher Education Personnel (CAPES) for their support.

Funding

Brazilian Government agency Coordination for the Improvement of Higher Education Personnel (CAPES).

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Authors and Affiliations

  1. Postgraduate Program in Applied Science for Health Products, Faculty of Pharmacy, Fluminense Federal University, Rua Dr. Mario Viana, 523, Santa Rosa, Niterói, RJ, 24241-000, Brazil

    Mariana Souza Rocha & Samanta Cardozo Mourão

  2. Department of Management, Federal Institute of Education, Science and Technology Northern of Minas Gerais, Almenara, MG, Brazil

    Luiz Célio Souza Rocha

  3. Department of Galenic Innovation, Laboratory of Experimental Pharmacotechnics, Fundação Oswaldo Cruz (FIOCRUZ), Farmanguinhos – Manguinhos, Rio de Janeiro, Brazil

    Alessandra Lifsitch Viçosa & Thiago Frances Guimarães

  4. Faculty of Pharmacy, Fluminense Federal University, Rua Dr. Mario Viana, 523, Santa Rosa, Niterói, RJ, 24241-000, Brazil

    Paula Luiza Limongi dos Santos Marotta & Samanta Cardozo Mourão

  5. University Laboratory Rodolpho Albino, Fluminense Federal University, Rua Dr. Mario Viana, 523, Santa Rosa, Niterói, RJ, 24241-000, Brazil

    Carolina Esper Ferreira & Samanta Cardozo Mourão

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  1. Mariana Souza Rocha
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Rocha, M.S., Rocha, L.C.S., Viçosa, A.L. et al. Developing and Featuring Matrix Tablets by Using Gross Linseed Mucilage as a Retardant Polymer. J Pharm Innov 17, 472–484 (2022). https://doi.org/10.1007/s12247-020-09523-4

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