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Optimized ciprofloxacin release from citric acid crosslinked starch-PVA hydrogel film: modelling with mixture design

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Abstract

Projecting optimal composition for hydrogel blends, while designing sustained release formulation of hydrophilic drug, is of paramount importance. In present study, composite hydrogel incorporating ciprofloxacin (0.2% w/w) was prepared by sequential addition of polyvinyl alcohol (PVA) (20–95% w/w), starch (0–75% w/w), citric acid (5–80% w/w) as cross-linker in a heat-induced gelatinization process. A constrained simplex mixture design was adopted to rationalize the proportion of ingredients in hydrogel composition while modelling the time required for 50% drug release from the hydrogel under in-vitro conditions. Prepared hydrogels were also characterized for swelling ratio, tensile strength, and antimicrobial disc-diffusion assay. Decreasing proportion of starch relative to PVA results in a transparent hydrogel, with a high degree of equilibrium swelling (up to 104%). Drug release from all hydrogel blend arguably followed Korsmeyer-Peppas release kinetics with quasi-Fickian to non-Fickian release behaviour. The time required for 50% drug release and the hydrogel dissolution was proportional, indicating disintegration-controlled release rate. Reduced cubic-model based on the forward selection offered good agreement with experimental data (R2, 0.98 and adjusted R2 of 0.91). Optimal blend projection by the model with a mass ratio of 0.38:0.21:0.41 for PVA: Starch: citric acid was verified to be reasonably correct.

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  1. Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore, 641114, India

    Jennifer David & Biswanath Mahanty

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  1. Jennifer David
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David, J., Mahanty, B. Optimized ciprofloxacin release from citric acid crosslinked starch-PVA hydrogel film: modelling with mixture design. J Polym Res 28, 20 (2021). https://doi.org/10.1007/s10965-020-02397-7

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