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Study of the Extremely-Tolerant Brevibacterium linens AE038-8 with Antiviral Activity Against Herpes Simplex Virus Type 1

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Abstract

Brevibacterium linens AE038-8 is an arsenic hyper-tolerant bacterial strain, previously isolated from well water in Tucumán, Argentina. The aim of this study was to characterize this strain regarding its resistance to different stress factors and to evaluate its antiviral activity against Herpes simplex virus type 1 (HSV-1). We found that B. linens AE038-8 was capable of tolerating high concentrations of heavy metals such as Cd(II), Cr(VI) and Cu(II). When grown in the presence of NaCl, it could tolerate up to 3 M in LB25 medium. When cultivated, B. linens released to the supernatants a bioactive principle with antiviral activity against HSV-1 virus regardless growth conditions.

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Acknowledgements

The authors acknowledge financial support from Project PICT 2013-1768 to PJDM, PICT 2013-2281 to LEA and PICT 2008-312 to MAF; from the Ministerio de Ciencia y Tecnología (MINCyT), Argentina.

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Authors and Affiliations

  1. Instituto de Astronomía y Física del Espacio, CONICET, Universidad de Buenos Aires, C1428ZAA, Buenos Aires, Argentina

    Daniela Maizel & Pablo Jacobo David Mauas

  2. Buenos Aires Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Virología, Universidad de Buenos Aires, Buenos Aires, Argentina

    Franco Maximiliano Salinas, Inés Solórzano & Laura Edith Alché

  3. Buenos Aires Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Microbiología Ambiental y Nanotecnología, Universidad de Buenos Aires, Buenos Aires, Argentina

    Laura Raiger Iustman

  4. CONICET, Universidad de Buenos Aires, Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), C1428ZAA, Buenos Aires, Argentina

    Daniela Maizel, Franco Maximiliano Salinas, Laura Raiger Iustman & Laura Edith Alché

  5. PROIMI-CONICET- Universidad Nacional de Tucumán, 4000, Tucumán, Argentina

    Marcela Alejandra Ferrero

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  1. Daniela Maizel
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  2. Franco Maximiliano Salinas
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  4. Laura Raiger Iustman
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  6. Pablo Jacobo David Mauas
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  7. Laura Edith Alché
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Correspondence to Laura Edith Alché.

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Maizel, D., Salinas, F.M., Solórzano, I. et al. Study of the Extremely-Tolerant Brevibacterium linens AE038-8 with Antiviral Activity Against Herpes Simplex Virus Type 1. Curr Microbiol 78, 688–695 (2021). https://doi.org/10.1007/s00284-020-02316-5

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  • DOI: https://doi.org/10.1007/s00284-020-02316-5

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