Induced Positive Affect Reduces the Magnitude of the Startle Response and Prepulse Inhibition
Abstract
Abstract. The startle response is a reflex that represents a form of adaptation to environmental changes potentially relevant to survival. Startle magnitude can change depending on a number of factors such as the affective state of the organism during the presentation of the startle-inducing stimulus, or the so-called Prepulse Inhibition (PPI) that occurs when the startling stimulus (or Pulse) is preceded by a low-intensity stimulus (or Prepulse). This paper describes an experiment designed to analyze the impact of an induced positive affect on the magnitude of the startle response and PPI in adult humans. Specifically, each participant received alternating exposures to a picture of a face of a loved person (positive affect condition) or to a picture of a face of an unknown person (control condition) while the startle response and PPI were recorded. The results showed a decrease in both the magnitude of the startle response and percent PPI on the positive affect trials when compared with the control trials. These results are interpreted from psychophysiological and psychological perspectives considering the role of emotions in adaptive behavior.
References
2013). DSM-V. Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: American Psychiatric Publishing.
. (1999). A neuropsychological theory of positive affect and its influence on cognition. Psychological Review, 106, 529–550. https://doi.org/10.1037/0033-295x.106.3.529
(2002).
(The effects of positive affect and arousal on working memory and executive attention: Neurobiology and computational models . In S. MooreM. OaksfordEds., Emotional contagion: From brain to behavior (pp. 245–287). Amsterdam, The Netherlands: Benjamins. https://doi.org/10.1075/aicr.44.11ash2010). Dopamine is released in the striatum during human emotional processing. Neuroreport, 21, 1172–1176. https://doi.org/10.1097/WNR.0b013e3283410955
(1995). Principles of behavioral neuroscience. Chicago, IL: Brown & Benchmark.
(2002). Influence of affective and cognitive judgments on autonomic parameters during inhalation of pleasant and unpleasant odors in humans. Neuroscience Letters, 319, 162–166. https://doi.org/10.1016/S0304-3940(01)02572-1
(2015). Presidential Address 2014: The more-or-less interrupting effects of the startle response. Psychophysiology, 52, 1417–1431. https://doi.org/10.1111/psyp.12506
(2005). Committee report: Guidelines for human startle eyeblink electromyographic studies. Psychophysiology, 42, 1–15. https://doi.org/10.1111/j.1469-8986.2005.00271.x
(2001). Emotion and motivation I: Defensive and appetitive reactions in picture processing. Emotion, 1, 276–298. https://doi.org/10.1037/1528-3542.1.3.276
(1990). Startle reflex modification: emotion or attention? Psychophysiology, 27, 513–522. https://doi.org/10.1111/j.1469-8986.1990.tb01966.x
(1996). Picture media and emotion: Effects of a sustained affective context. Psychophysiology, 33, 662–670. https://doi.org/10.1111/j.1469-8986.1996.tb02362.x
(1994). Measuring emotion: The self-assessment manikin and the semantic differential. Journal of Behavior Therapy and Experimental Psychiatry, 25, 49–59. https://doi.org/10.1016/0005-7916(94)90063-9
(2000). Affective reactions to acoustic stimuli. Psychophysiology, 37, 204–215. https://doi.org/10.1017/S0048577200990012
(2007).
(The International Affective Picture System (IAPS) in the study of emotion and attention . In J. A. CoanJ. J. B. AllenEds., Handbook of emotion elicitation and assessment (pp. 29–46). New York, NY: Oxford University Press.2018). Startle reflex modulation during threat of shock and “threat” of reward. Psychophysiology, 55, e12989. https://doi.org/10.1111/psyp.12989
(2001). Human studies of prepulse inhibition of startle: Normal subjects, patient groups, and pharmacological studies. Psychopharmacology, 156, 234–258. https://doi.org/10.1007/s002130100810
(2004). Emotional responses to pictures of oneself in healthy college age females. Motivation and Emotion, 28, 279–295. https://doi.org/10.1023/B:MOEM.0000040155.79452.23
(1996). Sensorimotor gating in boys with Tourette’s syndrome and ADHD: Preliminary results. Biological Psychiatry, 39, 33–41. https://doi.org/10.1016/0006-3223(95)00101-8
(2013). Exploring eye-blink startle response as a physiological measure for affective computing. Proceedings of the Humaine Association Conference on Affective Computing and Intelligent Interaction. Geneva, Switzerland: IEEE, 227–232. https://doi.org/10.1109/ACII.2013.44
(2002). Modulación emocional de la respuesta de sobresalto
([Emotional modulation of the startle response] . Psicothema, 14, 106–111.2015). Emotion regulation of the affect-modulated startle reflex during different picture categories. Psychophysiology, 52, 1257–1262. https://doi.org/10.1111/psyp.12450
(1984).
(The mammalian startle response . In R. C. EatonEd., Neural mechanisms of startle behavior (pp. 287–351). Boston, MA: Springer. https://doi.org/10.1007/978-1-4899-2286-1_101993). Fear-potentiated startle: A neural and pharmacological analysis. Behavioural Brain Research, 58, 175–198. https://doi.org/10.1016/0166-4328(93)90102-V
(1982). A primary scoustic startle stimulation studies circuit: Lesion and stimulation studies. The Journal of Neuroscience, 2, 781–805.
(1999). Startle modification: Implications for neuroscience, cognitive science, and clinical science. Cambridge, UK: Cambridge University Press.
(2012). Different effects of unexpected changes in environmental conditions on prepulse inhibition in rats and humans. Physiology and Behavior, 106, 542–547. https://doi.org/10.1016/j.physbeh.2012.03.036
(2014). Startle response and prepulse inhibition modulation by positive- and negative-induced affect. International Journal of Psychophysiology, 91, 73–79. https://doi.org/10.1016/j.ijpsycho.2013.10.017
(2016). Effect of stress and attention on startle response and prepulse inhibition. Physiology and Behavior, 165, 179–186. https://doi.org/10.1016/j.physbeh.2016.07.022
(1984). Neural mechanisms of startle behavior. New York, NY: Plenum Press.
(2011). Age-related affective modulation of the startle eyeblink response: Older adults startle most when viewing positive pictures. Psychology and Aging, 26, 752–760. https://doi.org/10.1037/a0023110
(1998). The psychological significance of human startle eyeblink modification: A review. Biological Psychology, 47, 1–43. https://doi.org/10.1016/S0301-0511(97)00020-3
(2014). Modulación del reflejo de sobresalto en población colombiana: Evidencia de la interacción entre emoción y motivación
([Startle reflex modulation in a Colombian population: Evidence of the interaction between emotion and motivation] . Universitas Psychologica, 14, 157–164. https://doi.org/10.11144/Javeriana.upsy14-1.mrsp1982). Habituation of the blink reflex in normals and schizophrenic patients. Psychophysiology, 19, 1–6. https://doi.org/10.1111/j.1469-8986.1982.tb02589.x
(1998).
(Measurement of startle response, prepulse inhibition, and habituation . In J. N. CrawleyC. R. GerfenR. McKayM. A. RogawskiD. R. SibleyP. SkolnickEds., Current protocols in neuroscience (pp. 8.7.1–8.7.15). New York, NY: Wiley. https://doi.org/10.1002/0471142301.ns0807s031991). Fear‐potentiated startle in humans: Effects of anticipatory anxiety on the acoustic blink reflex. Psychophysiology, 28, 588–595. https://doi.org/10.1111/j.1469-8986.1991.tb01999.x
(2003). A review of the modulation of the startle reflex by affective states and its application in psychiatry. Clinical Neurophysiology, 114, 1557–1579. https://doi.org/10.1016/S1388-2457(03)00202-5
(2002). Emotion regulation: Affective, cognitive, and social consequences. Psychophysiology, 39, 281–291. https://doi.org/10.1017/S0048577201393198
(2011). Filial versus romantic love: Contributions from peripheral and central electrophysiology. Biological Psychology, 88, 196–203. https://doi.org/10.1016/j.biopsycho.2011.08.002
(2012). Viewing loved faces inhibits defense reactions: A health-promotion mechanism? PLoS One, 7, 41631. https://doi.org/10.1371/journal.pone.0041631
(2000). Independence of valence modulation and prepulse inhibition of startle. Psychophysiology, 37, 5–12.
(2003). Affective modulation and prepulse inhibition of startle among undergraduates high and low in behavioral inhibition and approach. Psychophysiology, 40, 131–138. https://doi.org/10.1111/1469-8986.00013
(1963). Startle reaction: Modification by background acoustic stimulation. Science, 141, 928–930.
(2005). Sustained activation of the hippocampus in response to fearful faces in schizophrenia. Biological Psychiatry, 57, 1011–1019. https://doi.org/10.1016/J.BIOPSYCH.2005.01.033
(2015). Glutamate and dopamine in schizophrenia: An update for the 21st century. Journal of Psychopharmacology, 29, 97–115. https://doi.org/10.1177/0269881114563634
(1993). The molecular foundations of psychiatry. Washington, DC: American Psychiatric Press.
(1996). Pleasure-attenuation of startle is disrupted by lesions of the nucleus accumbens. Neuroreport, 7, 1442–1446. https://doi.org/10.1097/00001756-199605310-00024
(1997). The acoustic startle response in rats – circuits mediating evocation, inhibition and potentiation. Behavioural Brain Research, 89, 35–49. https://doi.org/10.1016/S0166-4328(97)02296-1
(1995). The emotion probe: Studies of motivation and attention. American Psychologist, 50, 372–385. https://doi.org/10.1037/0003-066X.50.5.372
(1990). Emotion, attention, and the startle reflex. Psychological Review, 97, 377–395. https://doi.org/10.1037/0033-295X.97.3.377
(1992). A motivational analysis of emotion: Reflex-cortex connections. Psychological Science, 3(1), 44–49. https://doi.org/10.1111/j.1467-9280.1992.tb00255.x
(1997). International affective picture system (IAPS): Technical manual and affective ratings. Psychology, 77, 1–5. https://doi.org/10.1016/j.epsr.2006.03.016
(1998). Emotion, motivation, and anxiety: Brain mechanisms and psychophysiology. Biological Psychiatry, 44, 1248–1263.
(2016). Modulation of prepulse inhibition and startle reflex by emotions: A comparison between young and older adults. Frontiers in Aging Neuroscience, 8, 33. https://doi.org/10.3389/fnagi.2016.00033
(2001). Novelty-evoked elevations of nucleus accumbens dopamine: Dependence on impulse flow from the ventral subiculum and glutamatergic neurotransmission in the ventral tegmental area. European Journal of Neurosciece, 13, 819–828. https://doi.org/10.1046/j.0953-816x.2000.01448.x
(2014). Neurophysiological biomarkers informing the clinical neuroscience of schizophrenia: Mismatch negativity and prepulse inhibition of startle. Current Topics in Behavioral Neurosciences, 21, 293–314. https://doi.org/10.1007/7854_2014_316
(2001). Assessing the effects of attention and emotion on startle eyeblink modulation. Journal of Psychophysiology, 15, 173–182.
(2018). Suppressed acoustic startle response in traumatic brain injury masks post-traumatic stress disorder hyper-responsivity. Neuroreport, 29, 939–944. https://doi.org/10.1097/WNR.0000000000001056
(2017). Habituation is altered in neuropsychiatric disorders – a comprehensive review with recommendations for experimental design and analysis. Neuroscience & Biobehavioral Reviews, 80, 286–305. https://doi.org/10.1016/j.neubiorev.2017.05.028
(2016). Reduced prepulse inhibition as a biomarker of schizophrenia. Frontiers in Behavioral Neuroscience, 10, 202. https://doi.org/10.3389/fnbeh.2016.00202
(1987). Cerebral processing of nonverbal affective stimuli: Differential effects of cognitive and affective sets on hemispheric asymmetry. Biological Psychology, 24, 67–84. https://doi.org/10.1016/0301-0511(87)90100-1
(1994). Importance of unpredictability for reward responses in primate dopamine neurons. Journal of Neurophysiology, 72, 1024–1027. https://doi.org/10.1152/jn.1994.72.2.1024
(2015). Affective modulation of brain and autonomic responses in patients with Fibromyalgia. Psychosomatic Medicine, 77, 721–732. https://doi.org/10.1097/PSY.0000000000000217
(2009). Modulation of the startle reflex by pleasant and unpleasant music. International Journal of Psychophysiology, 71, 37–42. https://doi.org/10.1016/j.ijpsycho.2008.07.010
(1974). Distinguishing anger and anxiety in terms of emotional response factors. Journal of Consulting and Clinical Psychology, 42, 79–83. https://doi.org/10.1037/h0035915
(1998). The effects of caffeine and directed attention on acoustic startle habituation. Pharmacology, Biochemistry, and Behavior, 59, 145–150. https://doi.org/10.1016/s0091-3057(97)00384-5
(2009). Attenuation of auditory startle and prepulse inhibition by unexpected changes in ambient illumination through dopaminergic mechanisms. Behavioural Brain Research, 197, 251–261. https://doi.org/10.1016/j.bbr.2008.08.030
(1995). Conditioned pleasure attenuates the startle response in rats. Neurobiology of Learning and Memory, 64, 1–3. https://doi.org/10.1006/nlme.1995.1037
(2000). Animal models of deficient sensorimotor gating: What we know, what we think we know, and what we hope to know soon. Behavioural Pharmacology, 11, 185–204.
(2001). Tactile prepuff inhibition of startle in children with Tourette’s syndrome: In search of an “fMRI-friendly” startle paradigm. Biological Psychiatry, 50, 578–585.
(2003). Amphetamine effects on prepulse inhibition across-species: Replication and parametric extension. Neuropsychopharmacology, 28, 640–650. https://doi.org/10.1038/sj.npp.1300086
(2007). Anxiety and defensiveness: Individual differences in affective startle modulation. Motivation and Emotion, 31, 115–123. https://doi.org/10.1007/s11031-007-9062-0
(2010). Affective processing of loved faces: Contributions from peripheral and central electrophysiology. Neuropsychologia, 48, 2894–2902. https://doi.org/10.1016/j.neuropsychologia.2010.05.031
(1988). The startle probe response: A new measure of emotion? Journal of Abnormal Psychology, 97, 487–491. https://doi.org/10.1037/0021-843X.97.4.487
(1985). Toward a consensual structure of mood. Psychological Bulletin, 98, 219–235.
(2006). Midbrain pathways for prepulse inhibition and startle activation in rat. Neuroscience, 142, 921–929. https://doi.org/10.1016/j.neuroscience.2006.06.025
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