The synthesis of previously unknown nitriles, esters, and an amide of 6-alkoxy-2-alkylsulfanyl-4-methyl(4,4-dimethyl)nicotinic acid has been developed. The structure of a number of the obtained derivatives was proved by X-ray structural analysis.
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(a) Clément, A.; Arquint, A.; Lauk, U. US Patent 7169909 B2. [RZhKhim. 2007, 07.20-19H.213П.] (b) Egli, R. US Patent 7125966 B2. [RZhKhim. 2007, 07.18-19N.166P.] (c) Carlini, R.; Duff, J. M.; Robinson, S. G.; Liebermann, G.; Gaynor, R. E.; Pereira, T.; Banning, J. H.; Mayo, J. D. US Patent 6576747 B1. [RZhKhim. 2004, 04.02-19N.144P.]
Buryi, D. S.; Dotsenko, V. V.; Aksenov, N. A.; Aksenova, I. V.; Krivokolysko, S. G.; Dyadyuchenko, L. V. Russ. J. Gen. Chem. 2019, 89, 1575. [Zh. Obshch. Khim. 2019, 89, 1182.]
Dmitrieva, I. G.; Dyadyuchenko, L. V.; Strelkov, V. D.; Konyushkin, L. D.; Kaigorodova, E. A. RF Patent 2300527. [RZhKhim. 2007, 07.19-19O.359П.]
Elkholy, Y. M. Chem. Heterocycl. Compd. 2002, 38, 1342. [Khim. Geterotsikl. Soedin. 2002, 1525.]
Darvesh, S.; Magee, D.; Valenta, Z.; Martin, E. US Patent 6436972 B1.[ RZhKhim. 2002, 03.07-19O.87П.]
(a) Semichenko, E. S.; Vasilenko, F. N.; Tovbis, M. S.; Belyae, E. Yu. Russ. J. Org. Chem. 2005, 41, 313. [Zh. Org. Khim. 2005, 41, 319.] (b) Boominathan, M.; Nagaraj, M.; Muthusubramanian, S.; Krishnakumar, R. V. Tetrahedron 2011, 67, 6057. b Zink, M.; Lanig, H.; Troschütz, R. Eur. J. Med. Chem. 2004, 39, 1079.
Dyachenko, V. D.; Dyachenko, A. D. Ukr. Khim. Zh. 2008, 74(9), 59.
(a) Dyachenko, I. V.; Dyachenko, V. D.; Dorovatovskii, P. V.; Khrustalev, V. N.; Nenajdenko, V. G. Chem. Heterocycl. Compd. 2019, 55, 442. [Khim. Geterotsikl. Soedin. 2019, 55, 442.] (b) Dyachenko, V. D.; Chernega, A. N. Chem. Heterocycl. Compd. 2005, 41, 890. [Khim. Geterotsikl. Soedin. 2005, 1053.] (c) Kalashnik, I. N.; Dyachenko, V. D. Russ. J. Gen. Chem. 2020, 90, 357. [Zh. Obsh. Khim. 2020, 90, 371.] (d) Dyachenko, I. V.; Dyachenko, V. D. Russ. J. Gen. Chem. 2015, 85, 1043. [Zh. Obshch. Khim. 2015, 85, 745.]
Dotsenko, V. V.; Frolov, K. A.; Chigorina, E. A.; Khrustaleva, A. N.; Krivokolysko, S. G. Russ. Chem. Bull., Int. Ed. 2019, 68, 691. [Izv. Akad. Nauk, Ser. Khim. 2019, 691.]
Dyachenko, V. D. Russ. J. Org. Chem. 2006, 42, 940. [Zh. Org. Khim. 2006, 42, 957.]
Dyachenko, V. D.; Dyachenko, A. D.; Chernega, A. N. Russ. J. Org. Chem. 2004, 40, 397. [Zh. Org. Khim. 2004, 40, 424.]
Battye, T. G. G.; Kontogiannis, L.; Johnson, O.; Powell, H. R.; Leslie, A.G.W. Acta Crystallogr., Sect. D: Biol. Crystallogr. 2011, D67, 271.
Evans, P. Acta Crystallogr., Sect. D: Biol. Crystallogr. 2006, D62, 72.
Sheldrick, G. M. Acta Crystallogr., Sect. C: Struct. Chem. 2015, C71, 3.
This work was supported by the Ministry of Science and Higher Education of the Russian Federation (project No. 075-03-2020-223 (FSSF-2020-0017)).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(12), 1579–1585
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Dyachenko, I.V., Dyachenko, V.D., Dorovatovskii, P.V. et al. Multicomponent synthesis of nicotinic acid derivatives. Chem Heterocycl Comp 56, 1579–1585 (2020). https://doi.org/10.1007/s10593-020-02852-9
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DOI: https://doi.org/10.1007/s10593-020-02852-9