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Biophysical approaches promote understanding of the viral replication cycle

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Abstract

In the last decades, various biophysical techniques have been developed to provide more detailed pictures of biological systems of interest. Virus is one of the systems where these new approaches have been most successful. Different stages of the viral replication cycle have been probed with a multitude of biophysical approaches, producing numerous novel findings. To do so, researchers adopted various biophysical techniques best suited to understand the multifarious mechanisms of viral replication. Here, we review biophysical studies on virus during the last decades. This paper aims to be a guide for physicists who are interested in applying their techniques to viruses, so we emphasize preferable experimental methods and their capabilities in the context of virus research. We also provide a brief introduction to the viral replication cycle to help readers understand relevant questions in the field.

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  • 21 January 2021

    The article was revised to change copy right year.

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Acknowledgements

The author gratefully acknowledges support by National Research Foundation of Korea grants 2017R1D1A1B03035671 and 2019R1C1C1007124.

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  1. Department of Physics Education, Kongju National University, Gongju, 32588, Republic of Korea

    Kyung Suk Lee

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Lee, K.S. Biophysical approaches promote understanding of the viral replication cycle. J. Korean Phys. Soc. 78, 329–342 (2021). https://doi.org/10.1007/s40042-020-00030-w

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