Abstract
The study reported in the present paper aimed to evaluate the effective energy (Eeff) of X-rays emitted from the surface of a bare X-ray probe and from different spherical applicators with various diameters, which are widely employed for low kV intraoperative radiotherapy (IORT) of breast cancer. A previously validated Monte Carlo model of the INTRABEAM system along with applicator diameters of 1.5–5 cm (with 0.5 cm increments) was employed for this purpose. The results show that the presence of the applicator can considerably harden the X-rays produced by the bare probe so that Eeff increases by a factor of about 2.6. Variations of applicator diameter also affects the X-ray effective energy. Specifically, increasing the applicator diameter from 1.5 to 3 cm and 3.5–5 cm resulted in an increase in the Eeff by 8.8% and 14.6%, respectively. The validity of the calculated Eeff values was confirmed by a reasonable agreement between the obtained probability density distributions (PDDs) for the full X-ray energy spectrum and those for the corresponding single effective energies, for different applicator diameters. The Eeff values obtained for different applicator diameters and the bare probe alone can be used as an alternative for the corresponding full energy spectra, in Monte Carlo-based dosimetry simulations of low-energy therapeutic X-rays, as well as for determining quality conversion factors of any ion chambers employed for low kV-IORT absolute dosimetry.
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References
Armoogum KS, Parry JM, Souliman SK, Sutton DG, Mackay CD (2007) Functional intercomparison of intraoperative radiotherapy equipment-photon radiosourgery system. Radiat Oncol 2:1–9
Avanzo M, Rink A, Dassie A, Massarut S, Roncadin M, Borsatti E, Capra E (2012) In vivo dosimetry with radiochromic films in low-voltage intraoperative radiotherapy of the breast. Med Phys 39:2359–2368
Beatty J, Biggs PJ, Gall K, Okunieff P, Pardo FS, Harte KJ et al (1996) A new miniature X-ray device for interstitial radiosurgery: dosimetry. Med Phys 23:53–62
Bouzid D, Bert J, Dupre PF, Benhalouche S, Pradier O, Boussion N, Visvikis D (2015) Monte-Carlo dosimetry for intraoperative radiotherapy using a low energy x-ray source. Acta Oncol 54:1788–1795
Chantler CT, Olsen K, Dragoset RD, Chang J, Kishore AR, Kotochigova SA, et al (2005) X-ray form factor, attenuation and scattering tables (version 2.1). In: Physical reference data. National institute of standard and technology (NIST). https://www.nist.gov/pml/x-ray-form-factor-attenuation-and-scattering-tables. Accessed 26 Dec 2019
Chetty J, Curran B, Cygler JE, DeMarco JJ, Ezzell G, Faddegon BA et al (2007) Report of the AAPM task group No. 105: Issues associated with clinical implementation of Monte Carlo-based photon and electron external beam treatment planning. Med Phys 34:4818–4853
Chiavassa S, Buge F, Hervé C, Delpon G, Rigaud J, Lisbona A et al (2015) Monte Carlo evaluation of the effect of inhomogeneities on dose calculation for low energy photons intra-operative radiation therapy in pelvic area. Phys Med 31:956–962
Clausen S, Schneider F, Jahnke L, Fleckenstein J, Hesser J, Glatting G et al (2012) A Monte Carlo based source model for dose calculation of endovaginal TARGIT brachytherapy with INTRABEAM and cylindrical applicator. Z Med Phys 22:197–204
Eaton DJ (2012) Quality assurance and independent dosimetry for an intraoperative X-ray device. Med Phys 39:6908–6920
Eaton DJ, Schneider F (2014) Radiation protection. In: Keshtgar M, Pigott K, Wenz F (eds) Targeted intraoperative radiotherapy in oncology. Springer, New York, pp 38–43
Geurts MW (2018) CalcGamma. GitHub. https://github.com/mwgeurts/gamma/blob/master/CalcGamma.m. Accessed 20 April 2020
Goer DA, Silverstein MJ (2014) The emerging role of intraoperative radiation therapy (IORT) in breast cancer. In: Riker AI (ed) Breast disease. Springer, New York, pp 413–461
Gonzalez R, Reynolds C (2014) How to use the INTRABEAM system. In: Keshtgar M, Pigott K, Wenz F (eds) Targeted intraoperative radiotherapy in oncology. Springer, New York, pp 13–30
Gunderson LL, Calvo FA, Willett CG, Harrison LB (2011) Rationale and historical perspective of intraoperative irradiation. In: Gunderson LL, Willett CG, Calvo FA, Harrison LB (eds) Intraoperative irradiation: techniques and results. Humana Press, New York, pp 3–26
Low DA, Harms WB, Mutic S, Purdy JA (1998) A technique for the quantitative evaluation of dose distributions. Med Phys 25:656–661
Moradi F, Ung NM, Khandaker MU, Mahdiraji GA, Saad M, Abdul Malik R, Bustam AZ, Zaili Z, Bradley DA (2017) Monte Carlo skin dose simulation in intraoperative radiotherapy of breast cancer using spherical applicators. Phys Med Biol 62(16):6550–6566
Njeh CF, Saunders MW, Langton CM (2010) Accelerated partial breast irradiation (APBI): a review of available techniques. Radiat Oncol l4:5–90
Nwankwo O, Clausen S, Schneider F, Wenz F (2013) A virtual source model of a kilo-voltage radiotherapy device. Phys Med Biol 58:2363–2375
Potemin S, Uvarov I, Vasilenko I (2015) Intraoperative radiotherapy in locally-advanced and recurrent rectal cancer: retrospective review of 68 cases. Transl Cancer Res 4:189–195
Rosser KE (1998) An alternative beam quality index for medium-energy x-ray dosimetry. Phys Med Biol 43:587–598
Schneider F, Greineck F, Clausen S, Mai S, Obertacke U, Reisand T et al (2011) Development of a novel method for intraoperative radiotherapy during kyphoplasty for spinal metastases (kypho-iort). Int J Radiat Oncol Biol Phys 81:1114–1119
Shamsabadi R, Baghani HR, Azadegan B, Mowlavi AA (2020a) Monte Carlo based analysis and evaluation of energy spectrum for Low-kV IORT spherical applicators. Z Med Phys 30:60–69
Shamsabadi R, Baghani HR, Azadegan B, Mowlavi AA (2020b) Influence of breast tissue composition on dosimetric characteristics of therapeutic low energy X-rays. Rad Phys Chem 177:109110
Vidal M, Ibáñez P, Guerra P, Valdivieso MF, Rodríguez R, Illana C, Udías JM (2019) Fast optimized Monte Carlo phase-space generation and dose prediction for low energy X-ray intra-operative radiation therapy. Phys Med Biol 64:075002
Yanch JC, Harte KJ (1996) Monte Carlo simulation of a miniature, radiosurgery x-ray tube using the ITS 3.0 coupled electron photon transport code. Med Phys 23:1551–1558
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Shamsabadi, R., Baghani, H.R., Mowlavi, A.A. et al. Effective energy assessment during breast cancer intraoperative radiotherapy by low-energy X-rays: A Monte Carlo study. Radiat Environ Biophys 60, 125–134 (2021). https://doi.org/10.1007/s00411-020-00887-2
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DOI: https://doi.org/10.1007/s00411-020-00887-2