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Nanoparticles of two ZnO Precursors as an Encapsulating Matrix of Mangiferin: Associated Studies to Cytotoxic Effects on Liver Cancer Cells Hep-G2 and Healthy Lung Cell Beas-2B

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Abstract

In recent years, metal oxides have been studied as an encapsulating matrix nevertheless, few studies the effect that can exist between different precursors to form this type of nanomaterials; In this paper, we compare its ability as a mangiferin (MG) nanoencapsulated. Phytochemical that has been studied for its generous biological properties like anti-inflammatory, antiproliferative, and others; the nanoparticles (NP’s) be synthesized with zinc nitrate and zinc acetate. The results showed modifications in the morphology of the ZnO associated with the precursor but, there is no significant difference between any treatment that is associated with antitopoisomerase activity however, ZnOA-MG is statistically the best treatment by reducing in greater proportion the production of COX-II prostaglandins (97.38 ± 7.09%) with a significant difference (p < 0.05) compared toCOX-I (68.02 ± 2.14%) but, it is not considered a selective treatment moreover ZnOA-MG proved to be the least hepatotoxic (IC50, 140.19 ± 13.10 µg/mL) while ZnON is the most cytotoxic for HEP-G2 and BEAS-2B (IC50, 51.27 ± 4.72 and 26.91 ± 3.21 µg/mL). All treatments change the morphology of erythrocytes to low concentrations (25 µg/mL). Therefore the MG load benefits the biological impact of ZnO.

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Acknowledgements

The FFR-C student thanks the National Council of Science and Technology of Mexico (CONACYT) for the grant number 787023 awarded for the development of postgraduate studies

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Authors and Affiliations

  1. Laboratorio Integral de Investigación en Alimentos, Tecnológico Nacional de México/I.T.Tepic, Avenida Tecnológico No 2595, Lagos del Country, CP 63175, Tepic, Nayarit, Mexico

    Francisco Fabián Razura-Carmona, Sonia G. Sáyago-Ayerdi, Efigenia Montalvo-González & Jorge Alberto Sánchez-Burgos

  2. Instituto de Farmacobiología, Universidad de la Cañada, Carretera Teotitlán-San Antonio Nanahuatipán, Km 1.7, Paraje Titlacuatitla, CP 68540, Teotitlán de Flores Magón, Oaxaca, Mexico

    Mayra Herrera-Martínez

  3. Laboratorio de Investigación en Materiales, Agua y Energía, División de Ciencias Agropecuarias e Ingenierías, Centro Universitario de Los Altos, Universidad de Guadalajara, Av. Rafael Casillas Aceves 1200, CP 47620, Tepatitlán de Morelos, Jalisco, Mexico

    Alejandro Pérez-Larios

  4. Departamento de Ingenierías Química y Bioquímica, Tecnológico Nacional de México/I.T.Morelia, Ave. Tecnológico 1500, Col. Lomas de Santiaguito, 58120, Morelia, Michoacan, Mexico

    Marco Vinicio Ramírez-Mares

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  1. Francisco Fabián Razura-Carmona
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Correspondence to Jorge Alberto Sánchez-Burgos.

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Razura-Carmona, F.F., Herrera-Martínez, M., Sáyago-Ayerdi, S.G. et al. Nanoparticles of two ZnO Precursors as an Encapsulating Matrix of Mangiferin: Associated Studies to Cytotoxic Effects on Liver Cancer Cells Hep-G2 and Healthy Lung Cell Beas-2B. J Clust Sci 33, 163–171 (2022). https://doi.org/10.1007/s10876-020-01957-7

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