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Efficacy of assisted reproductive technology after ovarian tissue transplantation in a cohort of 11 patients with or without associated infertility factors

  • Fertility Preservation
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

IVF treatment in women with grafted frozen-thawed ovarian tissue is associated with poor reproductive outcomes. The aim of this study was to evaluate the efficacy of ovarian tissue transplantation (OTT) followed by assisted reproductive technology (ART) in women with or without associated infertility factors.

Methods

This is a prospective cohort study with retrospective data collection including eleven women, four of whom having an infertility factor (IF), who had undergone OTT in one university center between 2005 and 2017, followed by ART in six in vitro fertilization (IVF) centers.

Results

In total, 25 of the 85 cycles initiated (29%) were canceled, resulting in 60 oocyte retrievals. Ninety-five oocytes were retrieved: 36 were abnormal or immature, 29/39 fertilized (74%) after ICSI and 13/20 (65%) after IVF. Thirty-five embryos were transferred in seven patients (5/7 patients without IF and 2/4 patients with IF). After ART, one patient with IF experienced two pregnancies, one resulting in a live birth. For all patients, pregnancy rates and live birth rates were 7.4% and 3.7% per embryo transfer, respectively. Nine pregnancies and four live births occurred after spontaneous conception in five patients without IF, none in the infertility group.

Conclusion

This study confirms that IVF treatment in women with grafted frozen-thawed ovarian tissue is associated with poor outcomes. However, the chances of natural conception are high in women without IF. Patients with IF, without the possibility of spontaneous pregnancy, should be informed of poor reproductive outcomes after OTT followed by ART.

Trial registration number

NCT02184806

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Acknowledgments

We would like to thank the hematologists and surgeons who referred their patients to us: Prof. Sylvie Castaigne, Prof. Alain Delmer, Prof. Bernard Desablens, Prof. Dominique Elias, Dr. Thierry Forge, Dr. Jean Gabarre, Dr. Reda Garidi, Dr. Kamel Ghomari, Dr. Hugo Gonzales, Dr. Catherine Lhommé, Prof. Philippe Merviel, Prof. Regis Peffault de Latour, Prof. Gérard Socié, Dr. Dan Stefanescu, Dr. Aliénor Xhaard.

We thank Dr. Hervé Oya for data management, Prof. Alain Mallet, Dr. Merry Mazmanian, Dr. Cécile Kedzia, project managers. We also thank Corinne Journo and Lilia Grira for technical assistance.

We thank Prof. Jim Thornton for kindly providing editorial assistance and critically reviewing the manuscript.

Funding

The ovarian tissue transplantation research protocol was supported by the “Agence de la Biomedecine” (AOR AMP 2007) (France’s biomedicine agency) and by the “Association Saint Louis,” a patient-funded charity.

Author information

Authors and Affiliations

  1. Department of Reproductive Medicine, Clinique de la Muette, 75116, Paris, France

    M. Vatel

  2. Division of Child Health, Department of Obstetrics and Gynaecology, University of Nottingham, Nottingham, UK

    A. Torre

  3. Department of Reproductive Medicine, Poissy Saint-Germain-en-Laye Hospital, 78300, Poissy, France

    B. Paillusson

  4. Department of Reproductive Medicine, Amiens Hospital, 80054, Amiens, France

    F. Scheffler

  5. Department of Reproductive Biology, Poissy Saint-Germain-en-Laye Hospital, 78300, Poissy, France

    M. Bergere

  6. Medicine and Reproductive Biology, University Hospital and School of Medicine, Picardy Jules Verne University, 80054, Amiens, France

    M. Benkhalifa

  7. Peritox-INERIS, UMR-I 01, Joint Research Centre, Picardy Jules Verne University, 80054, Amiens, France

    M. Benkhalifa

  8. Department of Reproductive Medicine, Brest Hospital, 29200, Brest, France

    M.-T. Le Martelot

  9. Department of Reproductive Medicine and Biology, Nantes Hospital, 44000, Nantes, France

    F. Leperlier & S. Mirallié

  10. Department of Gynecology and Obstetrics, Assistance Publique des Hôpitaux de Paris (AP-HP), Tenon Hospital, 75020, Paris, France

    L. Selleret

  11. Department of Reproductive Biology, Assistance Publique des Hôpitaux de Paris (AP-HP), Tenon Hospital, 75020, Paris, France

    M. Prades-Borio

  12. Department of Gynecology and Obstetrics, Les Bluets Hospital, 75012, Paris, France

    A. Neuraz

  13. Department of Reproductive Biology, Assistance Publique-Hôpitaux de Paris (AP-HP), Cochin Hospital, 75014, Paris, France

    V. Barraud-Lange

  14. Department of Hematology, Adolescents and Young Adults Unit, Fertility Preservation, Assistance Publique-Hôpitaux de Paris (AP-HP), Saint-Louis Hospital, 1 Avenue Claude Vellefaux, 75010, Paris, France

    N. Boissel & C. Poirot

  15. Paris University, EA3518, 75006, Paris, France

    N. Boissel

  16. Department of Obstetrics and Gynecology, Assistance Publique des Hôpitaux de Paris (AP-HP), Pitié-Salpétrière Hospital, 75013, Paris, France

    A. Fortin

  17. Médecine Sorbonne University, 75005, Paris, France

    C. Poirot

Authors
  1. M. Vatel
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  2. A. Torre
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  3. B. Paillusson
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  4. F. Scheffler
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  5. M. Bergere
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  6. M. Benkhalifa
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  7. M.-T. Le Martelot
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  8. F. Leperlier
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  9. S. Mirallié
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  10. L. Selleret
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  11. M. Prades-Borio
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  12. A. Neuraz
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  13. V. Barraud-Lange
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  14. N. Boissel
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  15. A. Fortin
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  16. C. Poirot
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Contributions

C.P. was responsible for the fertility preservation program and for the ovarian transplantation protocol. M.V. and C.P. designed the study, interpreted the data, and contributed to the writing and revision of the manuscript. M.V. collected all the data and contributed to the preparation of the original draft. B.P., A.T., F.S., MT.leM., F.L., L.S., and A.N. assessed fertility and were responsible for clinical ART after transplantation. M.PB., S.M., and M.B. were responsible for biological ART after ovarian tissue transplantation. V.BL was responsible for the ovarian tissue thawing program. N.B. contributed to data interpretation. A.F. performed the ovarian tissue transplantation procedure. All authors contributed to the writing and revision of the manuscript.

Corresponding author

Correspondence to C. Poirot.

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Vatel, M., Torre, A., Paillusson, B. et al. Efficacy of assisted reproductive technology after ovarian tissue transplantation in a cohort of 11 patients with or without associated infertility factors. J Assist Reprod Genet 38, 503–511 (2021). https://doi.org/10.1007/s10815-020-02033-9

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  • DOI: https://doi.org/10.1007/s10815-020-02033-9

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