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Journal of Environmental Pathology, Toxicology and Oncology

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Tomentosin Reduces Behavior Deficits and Neuroinflammatory Response in MPTP-Induced Parkinson's Disease in Mice

Volume 40, Issue 1, 2021, pp. 75-84
DOI: 10.1615/JEnvironPatholToxicolOncol.v40.i1.70
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ABSTRACT

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. Tomentosin is an active compound isolated from the I. viscosa plant that has extensive therapeutic value. In this exploration, the neuroprotective actions of tomentosin were investigated against MPTP-stimulated neuroinflammation in mice. PD was stimulated in C57/BL6 mice by injecting 20-mg/kg MPTP at 2-h intervals 4 times a day for 15 days simultaneously with tomentosin treatment. The rota-rod test, grasping test, and pole climbing test were executed to investigate the motor functioning of the test animals. Proinflammatory cytokines, reactive oxygen species, and myeloperoxidase were assayed using commercial ELISA kits. Superoxide dismutase enzyme levels were measured by the standard method. Expression of TLR-4/NF-κB was analyzed by Western blot. Brain tissues of investigational animals were analyzed microscopically. Tomentosin treatment of the MPTP-intoxicated PD mice promoted appreciable regains in body weight and noticeably prevented MPTP-stimulated impairments in motor function. In the PD mice, proinflammatory cytokine, ROS, and MPO levels were lowered by tomentosin, inhibited the TLR-4/NF-κB signaling pathway and prevented inflammation-mediated neuronal cell damage, and reduced glial cell damage and normalized ganglion layers. These findings confirmed the neuroprotective properties of tomentosin against MPTP-induced PD in mice.

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  2. El Omari Nasreddine, El Menyiy Naoual, Zengin Gokhan, Goh Bey Hing, Gallo Monica, Montesano Domenico, Naviglio Daniele, Bouyahya Abdelhakim, Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms, Separations, 8, 11, 2021. Crossref

  3. Siraki Arno G., The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery, Redox Biology, 46, 2021. Crossref

  4. Aydin Tuba, Saglamtas Ruya, Dogan Busra, Kostekci Evin, Durmus Rukiye, Cakir Ahmet, A new specific method for isolation of tomentosin with a high yield from Inula viscosa (L.) and determination of its bioactivities , Phytochemical Analysis, 33, 4, 2022. Crossref

  5. Kabeerdass Nivedhitha, Thangasamy Selvankumar, Murugesan Karthikeyan, Arumugam Natarajan, Almansour Abdulrahman I., Suresh Kumar Raju, Velmurugan Plalanivel, Vijayanand Selvaraj, Nooruddin Thajuddin, Mohanavel Vinayagam, Sivakumar Subpiramaniyam, Mathanmohun Maghimaa, Embedding green synthesized zinc oxide nanoparticles in cotton fabrics and assessment of their antibacterial wound healing and cytotoxic properties: An eco-friendly approach, Green Processing and Synthesis, 11, 1, 2022. Crossref

  6. Güçlü Ebru, Çınar Ayan İlknur, Dursun Hatice Gül, Vural Hasibe, Tomentosin induces apoptosis in pancreatic cancer cells through increasing reactive oxygen species and decreasing mitochondrial membrane potential, Toxicology in Vitro, 84, 2022. Crossref

  7. D’Amico Ramona, Impellizzeri Daniela, Genovese Tiziana, Fusco Roberta, Peritore Alessio Filippo, Crupi Rosalia, Interdonato Livia, Franco Gianluca, Marino Ylenia, Arangia Alessia, Gugliandolo Enrico, Cuzzocrea Salvatore, Di Paola Rosanna, Siracusa Rosalba, Cordaro Marika, Açai Berry Mitigates Parkinson’s Disease Progression Showing Dopaminergic Neuroprotection via Nrf2-HO1 Pathways, Molecular Neurobiology, 59, 10, 2022. Crossref

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