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Sorption and diffusion behavior of actinium(iii) ions in contact with hydroxyapatite as a transporter of medical radionuclides

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Abstract

The sorption of the actinium(iii) ions as 225,228Ac isotopes on hydroxyapatite (HAP) with various textures was studied. A “reverse” generator using an extraction chromatographic sorbent based on diglycolamide derivative (DGA Resin) was proposed for 228Ac production. The chemical yield of the product was ≥90%. The optimal acidity of the solution during sorption (pH 6–7) and the ratio of solid and liquid phases (20 mg of the sorbent per mL of the solution) were determined in preliminary experiments. The process kinetics is adequately described by pseudo-second-order model. The stationary state is reached rapidly (in 10 min) when a HAP suspension is used, whereas time (20–30 min) is needed for textured samples. The possibility of actinium ion diffusion within the bulk of these samples is shown. The diffusion coefficient of actinium estimated by diffusion in a wet HAP paste layer (one-dimensional model) was (1.0±0.2) • 10−7 cm2 s−1.

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References

  1. B. V. Egorova, O. A. Fedorova, S. N. Kalmykov, Russ. Chem. Rev., 2019, 88, 901.

    Article  CAS  Google Scholar 

  2. L. Marcu, E. Bezak, B. Allen, Critical Reviews in Oncology/Hematology, 2018, 123, 7.

    Article  PubMed  Google Scholar 

  3. A. Morgenstern, C. Apostolidis, F. Bruchertseifer, Semin. Nucl. Med., 2020, 50, 119.

    Article  PubMed  PubMed Central  Google Scholar 

  4. M. Sathekge, F. Bruchertseifer, M. Vorster, I. O. Lawal, O. Knoesen, J. Mahapane, D. Cindy, R. Florette, A. Maes, C. Kratochwi, T. Lengana, L.F. Giesel, C. Van de Wiele, A. Morgenstern, J. Nucl. Med., 2020, 61, 62.

    Article  CAS  PubMed  Google Scholar 

  5. M. Sathekge, F. Bruchertseifer, O. Knoesen, Eur J. Nucl. Med. Mol. Imaging, 2019, 46, 129.

    Article  CAS  PubMed  Google Scholar 

  6. F. Bruchertseifer, A. Kellerbauer, R. Malmbeck, A. Morgenstern, J. Labelled Comp. Radiopharm., 2019, 62, 794.

    Article  CAS  PubMed  Google Scholar 

  7. R. A. Aliev, S. V. Ermolaev, A. N. Vasiliev, V. S. Ostapenko, E. V. Lapshina, B. L. Zhuikov, N. V. Zakharov, V. V. Pozdeev, V. M. Kokhanyuk, B. F. Myasoedov, S. N. Kalmykov, Solvent Extraction and Ion Exchange, 2014, 32, 468.

    Article  CAS  Google Scholar 

  8. B. L. Zhuikov, Appl. Radiat. Isotop, 2014, 84, 48.

    Article  CAS  Google Scholar 

  9. K. John, Eur. J. Nucl. Med. Mol. Imaging, 2019, 46, S722.

    Google Scholar 

  10. C. Hoehr, F. Bénard, K. Buckley, J. Crawford, A. Gottberg, V. Hanemaayer, P. Kunz, K. Ladouceur, V. Radchenko, C. Ramogida, A. Robertson, T. Ruth, N. Zacchia, S. Zeisler, P. Schaffer, Phys. Procedia, 2017, 90, 200.

    Article  CAS  Google Scholar 

  11. B. L. Zhuikov, S. N. Kalmykov, S. V. Ermolaev, R. A. Aliev, V. M. Kokhanyuk, V. L. Matushko, I. G. Tananaev, B. F. Myasoedov, Radiochemistry, 2011, 53, 73.

    Article  CAS  Google Scholar 

  12. S. V. Ermolaev, B. L. Zhuikov, V. M. Kokhanyuk, V. L. Matushko, S. N. Kalmykov, R. A. Aliev, I. G. Tananaev, B. F. Myasoedov, Radiochim. Acta, 2012, 100, 223.

    Article  CAS  Google Scholar 

  13. C. Apostolidis, R. Molinet, J. McGinley, Appl. Radiat. Isotop, 2005, 62, 383.

    Article  CAS  Google Scholar 

  14. C. Shih, L. Blok, R. Niederkohr, A. Avins, J. Nucl. Med., 2019, 60, 2041.

    Google Scholar 

  15. A. S. Sobolev, R. A. Aliev, S. N. Kalmykov, Russ. Chem. Rev., 2016, 85, 1011.

    Article  CAS  Google Scholar 

  16. K. J. Harrington, S. Mohammadtah, P. S. Uster, D. Glass, A. M. Peters, J. S. Stewart, Clin. Cancer Res., 20017, 243.

  17. P. Datta, S. Ray, J. Labelled Comp. Radiopharm., 2020; DOI: https://doi.org/10.1002/jlcr.3839.

  18. L. Arazi, T. Cooks, M. Schmidt, Y. Keisari, I. Kelson, Phys. Med. Biol., 2007, 52, 5025.

    Article  CAS  PubMed  Google Scholar 

  19. S. B. Lee, H. W. Lee, T. D. Singh, Theranostics, 2017, 7, 926.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. J. Xie, K. Chen, J. Huang, Biomaterials, 2010, 31, 3016.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. J. V. Rojas, J. D. Woodward, N. Chen, A. J. Rondinone, C. H. Castano, S. Mirzadeh, Nucl. Med. Biol., 2015, 42, 614.

    Article  CAS  PubMed  Google Scholar 

  22. F. Chen, H. Hong, Y. Zhang, Radiolabeled Mesopor. Silica Nanoparticles ACS Nano, 2013, 7, 9027.

    CAS  Google Scholar 

  23. N. Larson, H. Ghandehari, Chem. Mater., 2012, 24, 840.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. K. K. Kamaleshwaran, D. Rajan, B. Krishnan, Indian J. Nucl. Med., 2015, 30, 47.

    Article  PubMed  PubMed Central  Google Scholar 

  25. A. S. Shinto, K. K. Kamaleshwaran, S. Chakraborty, World J. Nucl. Med., 2015, 14, 81.

    Article  PubMed  PubMed Central  Google Scholar 

  26. J. U. M. Calegaro, J. Machado, R. G. Furtado, Haemophilia, 2014, 20, 421.

    Article  CAS  PubMed  Google Scholar 

  27. J. Gómez del Río, P. Sanchez, P. J. Morando, D. S. Cicerone, Chemosphere, 2006, 64, 1015.

    Article  CAS  Google Scholar 

  28. A. Yasukawa, T. Yokoyama, K. Kandori, T. Ishikawa, Colloids Surf., A. Physicochem. Eng. Asp., 2007, 299, 203.

    Article  CAS  Google Scholar 

  29. A. G. Kazakov, A. V. Severin, J. Radioanal. Nucl. Chem., 2020, 5, 1.

    Google Scholar 

  30. A. V. Severin, I. A. Berezin, M. A. Orlova, T. P. Trofimova, A. Yu. Lupatov, A. V. Egorov, V. M. Pleshakov, Russ. Chem. Bull., 2020, 69, 665.

    Article  CAS  Google Scholar 

  31. J. Kozempel, M. Vlk, E. Malkova, A. Bajzikova, J. Barta, R. Santos-Oliveira, A. Malta Rossi, J. Radioanal. Nucl. Chem., 2015, 304, 443.

    Article  CAS  Google Scholar 

  32. A. V. Severin, M. A. Orlova, E. S. Shalamova, Russ. Chem. Bull., 2019, 68, 2197.

    Article  CAS  Google Scholar 

  33. P. Suchánková, E. Kukleva, K. Štamberg, P. Nykl, M. Sakmár, M. Vlk, J. Kozempel, Materials, 2020, 13, 1915.

    Article  PubMed Central  CAS  Google Scholar 

  34. A. Vasiliev, A. Severin, E. Lapshina, E. Chernykh, S. Ermolaev, S. Kalmykov, J. Radioanal. Nucl. Chem., 2017, 311, 1503.

    Article  CAS  Google Scholar 

  35. A. V. Severin, A. N. Vasiliev, A. V. Gopin, I. E. Vlasova, E. V. Chernykh, Radiochemistry, 2019, 61, 339.

    Article  CAS  Google Scholar 

  36. A. N. Vasiliev, Ph.D Thesis, M. V. Lomonosov Moscow State University, Moscow, 2016, 20 pp. (in Russian).

  37. A. N. Vasiliev, V. S. Ostapenko, E. V. Lapshina, S. V. Ermolaev, S. S. Danilov, B. L. Zhuikov, S. N. Kalmykov, Radiochimica Acta, 2016, 104, 539.

    Article  CAS  Google Scholar 

  38. A. V. Severin, D. A. Pankratov, Russ. J. Inorg. Chem., 2016, 61, 265.

    Article  CAS  Google Scholar 

  39. V. N. Rudin, V. F. Komarov, I. V. Melikhov, Sposob polucheniya suspenzii gidroksiapatita [Method of Preparing Hydroxyapatite Suspension], RF Patent No. 2122520, 1998.

  40. E. I. Suvorova, V. V. Klechkovskaya, V. F. Komarov, A. V. Severin, Crystallogr. Rep., 2006, 51, 881.

    Article  CAS  Google Scholar 

  41. A. V. Severin, V. F. Komarov, V. E. Bozhevol’nov, I. V. Melikhov, Russ. J. Inorg. Chem., 2005, 50, 72.

    Google Scholar 

  42. A. V. Severin, A. V. Gopin, A. N. Vasiliev, K. I. Enikeev, Radiokhimiya [Radiochemistry], 2020, 62, No. 6 (in Russian).

  43. R. Akkaya, J. Radioanal. Nucl. Chem., 2012, 292, 125.

    Article  CAS  Google Scholar 

  44. M. Prasad, S. Saxena, Indust. Eng. Chem. Res., 2004, 43, 1512.

    Article  CAS  Google Scholar 

  45. W. J. Weber, J. C. Morris, J. Sanit. Eng. Div. Am. Soc. Civ. Eng., 1963, 89, 31.

    Google Scholar 

  46. G. McKay, M. S. Otterburn, A. G. Sweeney, Water Res., 1980, 14, 15.

    Article  CAS  Google Scholar 

  47. G. McKay, J. Chem. Technol. Biotechnol., 1983, 33A, 196.

    CAS  Google Scholar 

  48. F. C. Wu, R. L. Tseng, R. S. Juang, Water Res., 2001, 35, 613.

    Article  CAS  PubMed  Google Scholar 

  49. J. S. Suk, Q. Xu, N. Kim, J. Hanes, L. M. Ensign, Adv. Drug Deliv. Rev., 2016, 99, 28.

    Article  CAS  PubMed  Google Scholar 

  50. M. Hosseinzade, S. R. Karimi, A. Valian, H. Nojehdehian, Biomed. Res., 2016, 27, 442.

    CAS  Google Scholar 

  51. V. Lobaz, R. Konefal, J. Pánek, M. Vlk, J. Kozempel, M. Petřík, M. Hrubý, Colloids Surf. B, Biointerfaces, 2019, 179, 143.

    Article  CAS  PubMed  Google Scholar 

  52. A. Morgenstern, C. Apostolidis, C. Kratochwil, M. Sathekge, L. Krolicki, F. Bruchertseifer, Curr. Radiopharm., 2018, 11, 200.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Chemistry Department, M. V. Lomonosov Moscow State University, Build. 3, 1 Leninskie Gory, 119991, Moscow, Russian Federation

    A. V. Severin, A. N. Vasiliev, A. V. Gopin & K. I. Enikeev

  2. Institute for Nuclear Research, Russian Academy of Sciences, 27 ul. Fizicheskaya, Troitsk, 108840, Moscow, Russian Federation

    A. N. Vasiliev

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  1. A. V. Severin
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  2. A. N. Vasiliev
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  3. A. V. Gopin
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  4. K. I. Enikeev
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Correspondence to A. V. Severin.

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This work was fi nancially supported by the Russian Foundation for Basic Research (Project No. 18-03-00432) and performed using research equipment of the Center for Collective Use of the Institute for Nuclear Research, Russian Academy of Sciences (contract with the Ministry of Education and Science No. 14.621.21.0014, unique identifi er RFMEF162117X0014).

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Severin, A.V., Vasiliev, A.N., Gopin, A.V. et al. Sorption and diffusion behavior of actinium(iii) ions in contact with hydroxyapatite as a transporter of medical radionuclides. Russ Chem Bull 69, 2286–2293 (2020). https://doi.org/10.1007/s11172-020-3041-y

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  • DOI: https://doi.org/10.1007/s11172-020-3041-y

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