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Specific features of amidoalkylation of 6-hydroxy-5-isopropyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

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Russian Chemical Bulletin Aims and scope

Abstract

During the synthesis of new structural analogs of isothiobarbamine, the amidoalkylation of 6-hydroxy-5-isopropyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one was found to give a mixture of mono-, di-, and trisubstituted products. Possible explanations for low regioselectivity of the reaction are given.

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Authors and Affiliations

  1. Volgograd State Technical University, 28 prosp. Lenina, 400005, Volgograd, Russian Federation

    I. A. Novakov, D. S. Sheikin, V. V. Chapurkin, M. B. Nawrozkij, I. A. Kirillov & E. A. Ruchko

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  1. I. A. Novakov
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  2. D. S. Sheikin
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  3. V. V. Chapurkin
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  4. M. B. Nawrozkij
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  5. I. A. Kirillov
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  6. E. A. Ruchko
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Correspondence to M. B. Nawrozkij.

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Dedicated to Academician of the Russian Academy of Sciences A. M. Muzafarov on the occasion of his 70th birthday.

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Novakov, I.A., Sheikin, D.S., Chapurkin, V.V. et al. Specific features of amidoalkylation of 6-hydroxy-5-isopropyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one. Russ Chem Bull 69, 2363–2369 (2020). https://doi.org/10.1007/s11172-020-3029-7

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  • DOI: https://doi.org/10.1007/s11172-020-3029-7

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