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Biomarkers as diagnostic tools for mycobacterial infections in cattle

Published online by Cambridge University Press:  28 December 2020

Hyun-Eui Park  and
Han Sang Yoo Open the ORCID record for Han Sang Yoo [Opens in a new window]
Hyun-Eui Park
Affiliation:
Department of Infectious Disease, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Republic of Korea
Han Sang Yoo*
Affiliation:
Department of Infectious Disease, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Republic of Korea Bio-MAX/N-Bio Institute, Seoul National University, Seoul, 08826, Republic of Korea
*
Author for correspondence: Han Sang Yoo, Department of Infectious Disease, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Republic of Korea. E-mail: yoohs@snu.ac.kr
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Abstract

Mycobacterial infections are widely distributed in animals and cause considerable economic losses, especially in livestock animals. Bovine paratuberculosis and bovine tuberculosis, which are representative mycobacterial infections in cattle, are difficult to diagnose using current-generation diagnostics due to their relatively long incubation periods. Thus, alternative diagnostic tools are needed for the detection of mycobacterial infections in cattle. A biomarker is an indicator present in biological fluids that reflects the biological state of an individual during the progression of a specific disease. Therefore, biomarkers are considered a potential diagnostic tool for various diseases. Recently, the number of studies investigating biomarkers as tools for diagnosing mycobacterial infections has increased. In human medicine, many diagnostic biomarkers have been developed and applied in clinical practice. In veterinary medicine, however, many such developments are still in the early stages. In this review, we summarize the current progress in biomarker research related to the development of diagnostic biomarkers for mycobacterial infections in cattle.

Keywords

Biomarkerbovine paratuberculosisbovine tuberculosiscattlediagnosis
Type
Review Article
Information
Animal Health Research Reviews , Volume 22 , Issue 1 , June 2021 , pp. 72 - 84
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Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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