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Polycaprolactone–Gelatin Membranes in Controlled Drug Delivery of 5-Fluorouracil

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Abstract

Nanofibers are known as promising carriers for anticancer drug delivery, particularly in postoperative local chemotherapy, through surgical grafting the membrane. In this study, blends of poly (ε‑caprolactone) (PCL) and gelatin (Ge) at various polymeric proportions were used for electrospinning of the nanofibers containing the anticancer drug of 5-Fluorouracil (5-FU). The electrospinning was performed at three different conditions to study the influence of processing parameters on the membrane properties. The morphology and tensile properties of the PCL-Ge nanofibers were reliant on the gelatin ratio and the processing condition. Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) outcomes demonstrated that 5-Fluorouracil (5-FU) was well distributed in the fiber matrix, forming H-bonds and in an amorphous state. Weight loss measurements and drug release study showed much faster degradation, and 5-FU releasing from the nanofibers contained a higher amount of gelatin. Studying the cytotoxicity of the 5-FU-loaded nanofibers showed that the P70G30FU had well restrained the survive, attachment, and proliferation of HT-29 colorectal cancer cells. Therefore, the 5-FU loaded PCL-Ge nanofibers have the ability of controlled drug release following the desired cancer treatment protocol.

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Authors and Affiliations

  1. Department of Textile Engineering, Isfahan University of Technology, 84156-83111, Isfahan, Iran

    Faezeh Ghahreman, Dariush Semnani & Elham Kaviannasab

  2. Department of Chemical Engineering, Isfahan University of Technology, 84156-83111, Isfahan, Iran

    Saied Nouri Khorasani & Shahla Khalili

  3. Department of Pharmaceutics and Drug Delivery Systems Research Centre, Isfahan University of Medical Science, 81746-73461, Isfahan, Iran

    Jaleh Varshosaz

  4. Kiananobiovista Laboratory, 14816-34615, Tehran, Iran

    Sajjad Mohammadi

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  1. Faezeh Ghahreman
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Correspondence to Dariush Semnani.

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Faezeh Ghahreman, Semnani, D., Khorasani, S.N. et al. Polycaprolactone–Gelatin Membranes in Controlled Drug Delivery of 5-Fluorouracil. Polym. Sci. Ser. A 62, 636–647 (2020). https://doi.org/10.1134/S0965545X20330020

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