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6,7-Dialcoxy-Benzothiophene Derivatives as the Basis for Synthesis of Fluorescent Sensors for Reactive Oxygen Species

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Abstract

We suggest the use of the 6,7-dialcoxy-benzothiophene derivatives as the basis for synthesis of fluorescent sensors for reactive oxygen species. The corresponding dioxide, a potential product of oxidation, that might be generated during ROS detection, was synthesized. We have established that benzothiophene derivatives could be successfully used for synthesis of fluorescent sensors, due to the noticeable shift of the absorption and emission maxima that occurs during oxidation.

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Funding

The study was financially supported by the Russian Foundation for Basic Research (project no. 20-33-70266).

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, 117997, Moscow, Russia

    Ya. V. Bolt, A. S. Tsarkova & N. S. Baleeva

  2. Pirogov Russian National Research Medical University, 117997, Moscow, Russia

    A. S. Tsarkova

Authors
  1. Ya. V. Bolt
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  2. A. S. Tsarkova
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  3. N. S. Baleeva
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Corresponding author

Correspondence to N. S. Baleeva.

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This article does not contain any research involving humans and animals as research objects.

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The authors declare they have no conflict of interest.

Additional information

Abbreviations: ROS, reactive oxygen species; n-BuLi, n-butyllithium; AIBN, azobisisobutyronitrile; mCPBA, meta-chloroperbenzoic acid.

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Bolt, Y.V., Tsarkova, A.S. & Baleeva, N.S. 6,7-Dialcoxy-Benzothiophene Derivatives as the Basis for Synthesis of Fluorescent Sensors for Reactive Oxygen Species. Russ J Bioorg Chem 46, 1289–1292 (2020). https://doi.org/10.1134/S1068162020060035

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  • DOI: https://doi.org/10.1134/S1068162020060035

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