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Targeting Inflammation and Oxidative Stress as a Therapy for Ischemic Kidney Injury

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Abstract

Inflammation and oxidative stress are the main pathological processes that accompany ischemic injury of kidneys and other organs. Based on this, these factors are often chosen as a target for treatment of acute kidney injury (AKI) in a variety of experimental and clinical studies. Note, that since these two components are closely interrelated during AKI development, substances that treat one of the processes often affect the other. The review considers several groups of promising nephroprotectors that have both anti-inflammatory and antioxidant effects. For example, many antioxidants, such as vitamins, polyphenolic compounds, and mitochondria-targeted antioxidants, not only reduce production of the reactive oxygen species in the cell but also modulate activity of the immune cells. On the other hand, immunosuppressors and non-steroidal anti-inflammatory drugs that primarily affect inflammation also reduce oxidative stress under some conditions. Another group of therapeutics is represented by hormones, such as estrogens and melatonin, which significantly reduce severity of the kidney damage through modulation of both these processes. We conclude that drugs with combined anti-inflammatory and antioxidant capacities are the most promising agents for the treatment of acute ischemic kidney injury.

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Abbreviations

AKI:

acute kidney injury

IL:

interleukin

I/R:

ischemia/reperfusion

ROS:

reactive oxygen species

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Funding

This work was financially supported by the Russian Science Foundation (project no. 18-15-00058, the study of oxidative stress, hormones, and immunosuppressors) and by the Russian Foundation for Basic Research (project no. 19-34-90023, the study of inflammation).

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Authors and Affiliations

  1. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991, Moscow, Russia

    N. V. Andrianova, D. B. Zorov & E. Y. Plotnikov

  2. Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991, Moscow, Russia

    N. V. Andrianova

  3. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, 117997, Moscow, Russia

    D. B. Zorov & E. Y. Plotnikov

  4. Sechenov First Moscow State Medical University, Institute of Molecular Medicine, 119991, Moscow, Russia

    E. Y. Plotnikov

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  1. N. V. Andrianova
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Andrianova, N.V., Zorov, D.B. & Plotnikov, E.Y. Targeting Inflammation and Oxidative Stress as a Therapy for Ischemic Kidney Injury. Biochemistry Moscow 85, 1591–1602 (2020). https://doi.org/10.1134/S0006297920120111

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