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Adaptation of Mycoplasmas to Antimicrobial Peptides: Development of Melittin Resistance in Acholeplasma laidlawii Is Associated with Changes in Genomic and Proteomic Profiles and in Virulence

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

For the first time it is shown that the development of resistance to melittin in Acholeplasma laidlawii, a mycoplasma that is widely spread in nature and that is the main contaminant of cell cultures and vaccines, is associated with significant changes in the genomic profile, in cellular and vesicular proteomes, as well as in virulence.

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Funding

This work was performed under the state assignment of the Federal Research Center of the Kazan Scientific Center of the Russian Academy of Sciences, as well as partially supported by the Russian Foundation for Basic Research (project no. 18-04-00660). In this study, we used the equipment of the Interdisciplinary Core Facility of the Kazan Federal University with financial support of the Ministry of Education and Science of the Russian Federation (ID RFMEFI59414X0003).

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Authors and Affiliations

  1. Kazan Institute of Biochemistry and Biophysics, Federal Research Center Kazan Science Center of the Russian Academy of Sciences, Kazan, Russia

    V. M. Chernov, N. B. Baranova, A. A. Mouzykantov, E. S. Medvedeva & O. A. Chernova

  2. Kazan (Volga Region) Federal University, Kazan, Russia

    N. B. Baranova, M. A. Dramchini & O. A. Chernova

Authors
  1. V. M. Chernov
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  2. N. B. Baranova
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  3. A. A. Mouzykantov
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  4. E. S. Medvedeva
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  5. M. A. Dramchini
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  6. O. A. Chernova
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Corresponding author

Correspondence to N. B. Baranova.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by M. Batrukova

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Chernov, V.M., Baranova, N.B., Mouzykantov, A.A. et al. Adaptation of Mycoplasmas to Antimicrobial Peptides: Development of Melittin Resistance in Acholeplasma laidlawii Is Associated with Changes in Genomic and Proteomic Profiles and in Virulence. Dokl Biochem Biophys 495, 300–303 (2020). https://doi.org/10.1134/S1607672920060034

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  • DOI: https://doi.org/10.1134/S1607672920060034

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