Skip to main content
Log in

Biomineralization of Trabecular Meshwork in Open-Angle Glaucoma

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
  • Published:
Doklady Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

A new form of open-angle glaucoma has been identified, in which calcification and silicification of the trabecular meshwork is a potentially significant component of outflow obstruction. It is noted that the mineralization of this area is promoted by various disturbances in the acid–base balance in the tissue. The role of melanosomal enzymes in the initiation of the formation of mineral calcium phosphate in trabecular tissue in open-angle glaucoma is considered.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.

Similar content being viewed by others

REFERENCES

  1. Figueroa, M.P. and Lihón, J.S., Autofluorescent chalcedony in human brains from elderly patients, Biotech. Histochem., 2010, vol. 85, no. 3, pp. 171–176.

    Article  CAS  Google Scholar 

  2. LeGeros, R., Formation and transformation of calcium phosphates: relevance to vascular calcification, Z. Kardiol., 2001, vol. 90, no. 3, pp. 116–124.

    Article  Google Scholar 

  3. Mandel, S. and Tas, A.C., Brushite (CaHPO4 ⋅ 2H2O) to octacalcium phosphate (Ca8(HPO4)2(PO4)4 ⋅ 5H2O) transformation in DMEM solutions at 36.5°C, Mater. Sci. Eng. C, 2010, vol. 30, no. 2, pp. 245–254.

    Article  CAS  Google Scholar 

  4. Dorozhkin, S.V. and Epple, M., Biological and medical significance of calcium phosphates. Angew. Chem., Int. Ed., 2002, vol. 41, no. 17, pp. 3130–3146.

    Article  CAS  Google Scholar 

  5. Wang, L. and Nancollas, G.H., Calcium orthophosphates: crystallization and dissolution, Chem. Rev., 2008, vol. 108, no. 11, pp. 4628–4669.

    Article  CAS  Google Scholar 

  6. Pelkonen, L., Reinisalo, M., Morin-Picardat, E., et al., Isolation of intact and functional melanosomes from the retinal pigment epithelium, PLoS One, 2016, vol. 11, no. 8. e0160352.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to M. V. Kravchik.

Ethics declarations

Conflict of interest. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

Additional information

Translated by M. Batrukova

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kravchik, M.V., Subbot, A.M., Novikov, I.A. et al. Biomineralization of Trabecular Meshwork in Open-Angle Glaucoma. Dokl Biochem Biophys 495, 307–310 (2020). https://doi.org/10.1134/S1607672920060083

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1607672920060083

Keywords:

Navigation