Mimicking biosynthetic pathways can provide access to medicinally important natural products, but generating the reactive species used by nature can often be difficult. Now, a photoredox-based strategy has been developed to access a reactive radical intermediate postulated to be involved in complex lignan biosynthesis.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Walsh, C. T. & Moore, B. S. Angew. Chem. Int. Ed. 58, 6846–6878 (2019).
Poupon, E. & Nay, B. (eds) Biomimetic Organic Synthesis (Wiley-VCH, 2011).
Huang, Z. & Lumb, J.-P. Nat. Chem. https://doi.org/10.1038/s41557-020-00603-z (2020).
Li, X.-W. & Nay, B. Nat. Prod. Rep. 31, 533–549 (2014).
Okada, K., Okamoto, K., Morita, N., Okubo, K. & Oda, M. J. Am. Chem. Soc. 113, 9401–9402 (1991).
Prier, C. K., Rankic, D. A. & MacMillan, D. W. C. Chem. Rev. 113, 5322–5363 (2013).
Wang, G. Z., Shang, R. & Fu, Y. Org. Lett 20, 888–891 (2018).
Hung, K., Hu, X. & Maimone, T. J. Nat. Prod. Rep. 35, 174–202 (2018).
Romero, K. J., Galliher, M. S., Pratt, D. A. & Stephenson, C. R. J. Chem. Soc. Rev. 47, 7851–7866 (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Thach, D.Q., Maimone, T.J. Making light work of lignan synthesis. Nat. Chem. 13, 7–9 (2021). https://doi.org/10.1038/s41557-020-00604-y
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41557-020-00604-y
