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Pharmacological considerations of antibiotic failures in bovine respiratory disease cases

Published online by Cambridge University Press:  02 December 2020

Brian V. Lubbers Open the ORCID record for Brian V. Lubbers [Opens in a new window]
Brian V. Lubbers*
Affiliation:
Kansas State University, 1800 Denison Ave., Mosier Hall, Manhattan, KS66506, USA
*
Author for correspondence: Brian V. Lubbers, Kansas State University, 1800 Denison Ave., Mosier Hall, Manhattan, KS66506, USA. E-mail: blubbers@vet.k-state.edu
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Abstract

Bovine respiratory disease (BRD) is one of the most common indications for antimicrobial therapy in beef cattle production and research trials demonstrate that antibiotic therapy greatly improves clinical outcome for BRD. These trials also show that BRD treatment success rates are less than 100% and that there are opportunities to optimize antimicrobial prescribing and improve clinical outcomes if the underlying cause(s) of BRD treatment failures can be identified and addressed. As the etiology of BRD in an individual animal is frequently multi-factorial in nature; it is likely that BRD treatment failures also result from complex interactions between the drug, drug administrator, animal host, pathogens, and the environment. This review will focus specifically on the pharmacological aspects, specifically the interactions between the host and the drug and the drug and the drug administrator, of BRD treatment failures and the actions that veterinary practitioners can take to investigate and mitigate therapeutic failures in future cases.

Keywords

Antimicrobialsbovine respiratory diseasepharmacology
Type
Special issue: Papers from Bovine Respiratory Disease Symposium
Information
Animal Health Research Reviews , Volume 21 , Issue 2 , December 2020 , pp. 177 - 178
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Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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