Original ResearchMesenteric Neural Crest Cells Are the Embryological Basis of Skip Segment Hirschsprung’s Disease
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Graphical abstract
Keywords
Gastrointestinal Tract
Enteric Nervous System
Aganglionosis
EDN3/EDNRB Signaling Pathway
Abbreviations used in this paper
B-FABP
brain fatty acid-binding protein
CreERT
cre recombinase-mutated estrogen receptor
E
embryonic day
EDNRB
endothelin receptor type B
EDN3
endothelin 3
eNCC
enteric neural crest cell
ENS
enteric nervous system
ERBB3
human epidermal growth factor receptor 3
FLP
flippase
GDNF
glial cell-derived neurotrophic factor
GFP
green fluorescent protein
GI
gastrointestinal
HSCR
Hirschsprung’s disease
mNCC
mesenteric neural crest cell
NCC
neural crest cell
P
postnatal day
PBS
phosphate-buffered saline
PHOX2B
paired-like homeobox 2b
RET
ret proto-oncogene
SCP
Schwann cell precursor
sNCC
sacral neural crest cell
SOX10
sex determining region Y-box 10
SSHD
skip segment Hirschsprung’s disease
TCA
total colonic aganglionosis
tdTom
tandem dimer tomato
TM
tamoxifen
tmNCC
trans-mesenteric neural crest cell
TUJ1
neuron-specific class III beta-tubulin
vNCC
vagal neural crest cell
Wnt1
wingless-type MMTV integration site family member 1
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Conflicts of interest The authors disclose no conflicts.
Funding This work was supported by grants from the National Natural Science Foundation of China (82070527), the National Key R&D Program of China (2017YFA0104200), Zhejiang Provincial Natural Science Foundation of China (LY19C090005), the Fundamental Research Funds for the Central Universities (2019FZA7009), and the Chinese Ministry of Education Project 111 Program (B13026).
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Authors share co-first authorship.
© 2020 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.