Abstract—The aim of the study was to identify changes in serum concentrations of pro- and anti-inflammatory cytokines in workers exposed to metallic mercury vapors and in patients with chronic mercury intoxication (CMI), depending on the level of depression. We found unidirectional changes in the cytokine profile in workers with moderate and severe depression chronically exposed to vapors of metallic mercury, which include an increase in the production of proinflammatory IL-6 and TNF-α, and a decrease in IL-2. The most pronounced activity of inflammatory reactions was observed in subjects with moderate depression. In patients with severe depression associated with CMI, we found IL-4 overproduction associated with a decrease in the activation of pro-inflammatory reactions (IL-6, TNF-α) and an increase in IL-2 concentrations relative to subjects with moderate depression, which may reflect disturbance of the adequate functioning of the mechanisms cytokine regulation of the immune response. The revealed changes in the cytokine profile may be due to the comorbidity of depression with organic disorders of the nervous system characteristic of CMI, which can alter the state of the immune system. Further analysis of the role of inflammatory mediators in the pathophysiological mechanisms of the formation and development of depressive disorders will make it possible to more accurately determine objective risk criteria and develop preventive measures that will help to reduce the contribution of depression to the overall picture of neurointoxication.
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This study was supported by the state task of the East Siberian Institute of Medical and Environmental Research.
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Conflict of interest. The authors declare no conflict of interest.
Ethical approval. The examination of patients complied with ethical standards in accordance with the Declaration of Helsinki of the World Medical Association (2000) and the “Rules of Clinical Practice in the Russian Federation” approved by Order of the Ministry of Health of the Russian Federation No. 266 of June 19, 2003.
Informed consent. The studies were performed with the informed consent of patients and approved by the Ethics Committee of the East Siberian Research Center of Human Ecology of the Siberian Branch of the Russian Academy of Medical Sciences (Protocol No. 5 of November 14, 2012).
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Bodienkova, G.M., Boklazhenko, E.V. & Shevchenko, O.I. Changes in Inflammatory Mediators Depending on the Level of Depression in Workers Chronically Exposed to Mercury Vapors. Neurochem. J. 14, 439–443 (2020). https://doi.org/10.1134/S1819712420040029
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DOI: https://doi.org/10.1134/S1819712420040029