Abstract
RNA helicases are enzymes that exist in all domains of life whose canonical functions include ATP-dependent remodeling of RNA structures and displacement of proteins from ribonucleoprotein complexes (RNPs). These enzymes play roles in virtually all processes of RNA metabolism, including pre-mRNA splicing, rRNA processing, nuclear mRNA export, translation and RNA decay. Here we review emerging noncanonical substrates of RNA helicases including RNA-DNA hybrids (R-loops) and RNA and DNA G-quadruplexes and discuss their biological significance.
Funding source: Purdue University Center for Cancer Research
Award Identifier / Grant number: P30 CA023168
Award Identifier / Grant number: R01GM097332
Acknowledgements
We would like to thank Tran laboratory members Sara Cloutier and Youssef Hegazy for helpful input on this manuscript.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: This work was supported by funds from the Department of Biochemistry and Purdue University Center for Cancer Research (NIH grant P30 CA023168) and NIH R01GM097332 to E.J.T.
Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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