Abstract
The pathogenesis of diseases of the gastrointestinal tract in horses is accompanied by inflammation and oxidative stress and may be caused by a lack of nitric oxide, which controls various signaling pathways in the body. The level of nitrites, which are metabolites of nitric oxide in horses with various intestinal diseases, has been evaluated in blood serum at 3.60 ± 3.02 μM and 8.3 ± 6.0 μM in horses at ages of 7–26 years and 1–5 years, respectively. A sharp reduction in the nitrite concentrations was observed in all horses with intestinal diseases (3.39 ± 2.85 μM), especially in horses with tympanitic caecum (0.6 ± 0.4 μM) and obstruction of the colon (0.81 ± 0.5 μM).
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Abbreviations: DNIC—dinitrosyl iron complexes; ESR—electronic spin resonance; MGD—N-methyl-D,L-glucaminedithiocarbamate; MNIC—mononitrosyl iron complexes.
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Serezhenkov, V.A., Tkachev, N.A., Artyushina, Z.S. et al. Reduced Nitric Oxide Bioavailability in Horses with Colic: Evaluation by ESR Spectroscopy. BIOPHYSICS 65, 869–875 (2020). https://doi.org/10.1134/S0006350920050176
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DOI: https://doi.org/10.1134/S0006350920050176