Issue 1, 2021

Strategies to expand peptide functionality through hybridisation with a small molecule component

Abstract

Combining different compound classes gives molecular hybrids that can offer access to novel chemical space and unique properties. Peptides provide ideal starting points for such molecular hybrids, which can be easily modified with a variety of molecular entities. The addition of small molecules can improve the potency, stability and cell permeability of therapeutically relevant peptides. Furthermore, they are often applied to create peptide-based tools in chemical biology. In this review, we discuss general methods that allow the discovery of this compound class and highlight key examples of peptide–small molecule hybrids categorised by the application and function of the small molecule entity.

Graphical abstract: Strategies to expand peptide functionality through hybridisation with a small molecule component

Article information

Article type
Review Article
Submitted
14 Sep 2020
Accepted
09 Nov 2020
First published
08 Dec 2020
This article is Open Access
Creative Commons BY license

RSC Chem. Biol., 2021,2, 151-165

Strategies to expand peptide functionality through hybridisation with a small molecule component

Y. Wu, J. Williams, E. D. D. Calder and L. J. Walport, RSC Chem. Biol., 2021, 2, 151 DOI: 10.1039/D0CB00167H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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