Paper

Highly sensitive biosensor based on a microcantilever and alternating current electrothermal technology

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Published 7 December 2020 © 2020 IOP Publishing Ltd
, , Citation Lihao Wang et al 2021 J. Micromech. Microeng. 31 015009 DOI 10.1088/1361-6439/abcae6

0960-1317/31/1/015009

Abstract

This work presents a highly sensitive biosensor based on a microcantilever and alternating current (AC) electrothermal technology. The AC electrothermal unit was developed and integrated with the cantilever chip to improve the capture efficiency of the molecules under test. The AC electrothermal effect enhanced the aggregation of molecules around the microcantilever, increased their binding probability to the sensor and improved the detection performance of the biosensor. This microcantilever sensor was used to detect Vibrio parahaemolyticus and achieved a detection limit of ∼5 × 105 CFU ml−1, one order of magnitude lower than that of the sensor without AC electrothermal technology. Meanwhile, the detection time was reduced to 40 min, nearly half that of the conventional cantilever sensors.

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10.1088/1361-6439/abcae6