Chem
ArticleTopological Strain-Induced Regioselective Linker Elimination in a Chiral Zr(IV)-Based Metal-Organic Framework
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Zr-carboxylate metal-organic frameworks (MOFs) are well known as structurally robust materials with strong coordination bonds that have been widely investigated in the MOF community since 2008. The robust coordination of these 3D materials makes topology transitions involving Zr–O bond cleavage and formation extremely challenging and rare. Here, we demonstrate that by introducing a highly flexible 18-crown-6-ether functionality into a homochiral Zr-MOF, we are able to target an unprecedented SC-SC topology transition by the virtue of topological strain. The transition, which occurs without any external stimuli and through a regioselective-linker-elimination process, was captured by single-crystal and powder X-ray diffraction studies. As a result, a highly porous and stable 3D phase with fluorite topology is attained that can be employed as a solid adsorbent for enantioadsorptive and solid-phase extractive separation of lansoprazole, with an excellent enantioselectivity.
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