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Kinetics of superoxide-initiated reaction of nitroxides with cysteine

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Abstract

Kinetics of the reduction of nitroxides with cysteine in the presence of a source of superoxide radicals was studied. The reactivity of nitroxides in this process is determined by the reduction potential of the N-oxoammonium cation / nitroxide pair. The rate-limiting step of the reaction is the nitroxide oxidation by the hydroperoxyl radical to the N-oxoammonium cation.

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Correspondence to I. V. Tikhonov.

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This work was financially supported by the P. G. Demidov Yaroslavl State University (Project No. OP-2G-02-2019).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2097—2100, November, 2020.

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Tikhonov, I.V., Borodin, L.I., Sen, V.D. et al. Kinetics of superoxide-initiated reaction of nitroxides with cysteine. Russ Chem Bull 69, 2097–2100 (2020). https://doi.org/10.1007/s11172-020-3005-2

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  • DOI: https://doi.org/10.1007/s11172-020-3005-2

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