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Halogenation and nitration of 1-carboxymethyl-5-methyluracil. Halophilic reaction involving acetic anhydride

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Abstract

1-Carboxymethyl-5-halo-6-hydroxy-5-methyl-5,6-dihydrouracils and 1-carboxymethyl-6-hydroxy-5-methyl-5-mtro-5,6-dihydrouracils were synthesized for the first time by oxidative halogenation and nitration of 1-carboxymethyl-5-methyluracil. Dihydrouracil derivatives bearing a Br atom at position C(5) and a hydroxy group at position C(6) treated with Ac2O undergo deoxyhalogenation.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Federal Research Center of the Russian Academy of Sciences, 71 prosp. Oktyabrya, 450054, Ufa, Russian Federation

    I. B. Chernikova & M. S. Yunusov

Authors
  1. I. B. Chernikova
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  2. M. S. Yunusov
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Corresponding author

Correspondence to I. B. Chernikova.

Additional information

The spectral part of the study was carried out on the equipment of the “Khimiya” User Service Center of the Ufa Institute of Chemistry, Ufa Federal Research Center of the Russian Academy of Sciences.

This work was financially supported by the Ministry of Higher Education and Science of the Russian Federation (Topic No. AAAA-A20-120012090026-9).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2159—2162, November, 2020.

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Chernikova, I.B., Yunusov, M.S. Halogenation and nitration of 1-carboxymethyl-5-methyluracil. Halophilic reaction involving acetic anhydride. Russ Chem Bull 69, 2159–2162 (2020). https://doi.org/10.1007/s11172-020-3015-0

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  • DOI: https://doi.org/10.1007/s11172-020-3015-0

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