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An In situ Forming Hydrogel Based on Photo-Induced Hydrogen Bonding

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Abstract

Stimulus-induced in situ forming hydrogels possess the characteristics of easy management and minimal invasiveness via simple injection at target sites with a liquid and easy forming bulk gels. In the present study, a photoreactive monomer, N’-(2-nitrobenzyl)-N-acryloyl glycinamide (NBNAGA) was introduced to modify polyacrylamide (PAM) hydrogel preparation with stimuli responsiveness. Firstly, poly(acrylamide-co-N’-(2-nitrobenzyl)-N-acryloyl glycinamide), P(AM-co-NBNAGA), copolymer solution was prepared via reversible addition fragmentation chain transfer (RAFT) polymerization using the monomers mixture of AM, NBNAGA, and N,N’- methylene bis-acrylamide (BIS). The obtained polymer solution with viscous, transparent, and flowable appearance contained weak single hydrogen bonding and slight chemical crosslinking in a microscopic perspective. Secondly, without further purification, after irradiation using UV light at 365 nm, poly(acrylamide-co-N-acryloyl glycinamide) (P(AM-co-NAGA)) hydrogel conveniently in situ formed due to the cleavage of o-nitrobenzyl groups and the corresponding emergency of dual hydrogen bonding among “uncaged” dual amide moieties. P(AM-co-NAGA) hydrogel depicted both favorable temperature sensitivity and self-healing properties, then the heating induced in vitro release profiles of doxorubicin (DOX) was analyzed.

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Authors and Affiliations

  1. School of Materials and Chemical Engineering, Anhui Jianzhu University, Hefei, Anhui, 230022, P. R. China

    Jingyan Zhang, Shifeng Wang, Zeren Zhao, Dong Si, Haiou Zhou, Mingdi Yang & Xianbiao Wang

  2. CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, iChem (Collaborative Innovation Center of Chemistry for Energy Materials), Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China

    Jingyan Zhang

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  1. Jingyan Zhang
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  2. Shifeng Wang
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  3. Zeren Zhao
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  4. Dong Si
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  5. Haiou Zhou
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  6. Mingdi Yang
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  7. Xianbiao Wang
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Correspondence to Jingyan Zhang.

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Acknowledgments: The financial support from National Natural Science Foundation of China (21004001 and 21976003), College Quality Engineering Project of Anhui Province (2016gxk028), Anhui Provincial Natural Scientific Foundation (K10725), and Natural Scientific Foundation of Anhui Provincial Education Department (KJ2016JD15, KJ2019A0771, KJ2018A0514) is gratefully acknowledged.

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Zhang, J., Wang, S., Zhao, Z. et al. An In situ Forming Hydrogel Based on Photo-Induced Hydrogen Bonding. Macromol. Res. 28, 1127–1133 (2020). https://doi.org/10.1007/s13233-020-8153-6

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  • DOI: https://doi.org/10.1007/s13233-020-8153-6

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