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A New Approach to the Stimulation of the Body’s Defense Systems with Low Radiation Doses

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Abstract

The article considers the effects arising after exposure to low doses of radiation in vitro and in vivo, as well as the mechanisms of their formation. Analysis of the literature shows that the result of the action of low-dose radiation depends on the cell type, radiation sources, assessment methods, etc. This action differs from the effects of high doses and is associated with the activation of defense systems. Stimulation of the endogenous antioxidant system and repair was detected in normal cells after exposure to low doses. At the level of the organism, the response to the effect of low radiation doses is also accompanied by activation of the immune system. This leads to an increase in the resistance of normal cells to the action of genotoxic factors (the radio-adaptive response), which can be used to protect the normal tissues surrounding the tumor from the effects of high radiation doses during radiation therapy. The resistance of most malignant cells after irradiation with low doses did not change. However, the fractionated effect of low-dose radiation on the tumor could induce an increase in radio-sensitivity in malignant cells. The review presents data that show the change in the expression of a number of genes and regulatory RNA after exposure to low-dose radiation. These epigenetic parameters make it possible to explain individual differences in the magnitude of the radio-adaptive response. The paper discusses the prospects of the use of low-dose radiation for the treatment of certain human pathological conditions.

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REFERENCES

  1. Bevelacqua, J.J. and Mortazavi, S.M.J., Alzheimer’s disease: possible mechanisms behind neurohormesis induced by exposure to low doses of ionizing radiation, J. Boimed. Phys. Eng., 2018, vol. 8, no. 2, pp. 153–156.

    CAS  Google Scholar 

  2. Boaventura, P., Duraes, C., Mendes, A., and Costa, N., Is low dose radiation exposure a risk for atherosclerosis disease? Radiat. Res., 2018, vol. 189, no. 4, pp. 418–424.

    Article  CAS  Google Scholar 

  3. Cuttler, J.M., Moore, E.R., Hosfeld, V.D., and Nadolski, D.L., Update on a patient with Alzheimer disease treated with CT scans, Dose-Response, 2017, vol. 15, no. 1, pp. 1–2.

    Google Scholar 

  4. Danyaei, A., Khanbabaei, H., Teimoori, A., et al., Effect of intermittent low-dose irradiation on the radiotherapy efficiency for MDA-MB-231 human breast adenocarcinoma cell line, J. Radiat. Oncol., 2019, vol. 8, pp. 199–208.

    Article  CAS  Google Scholar 

  5. Doss, M., The importance of adaptive response in cancer prevention and therapy, Med. Phys., 2013, vol. 40, no. 3, p. e030401.

    Article  Google Scholar 

  6. Grant, E., Brenner, A., Sugiyama, H., et al., Solid cancer incidence among the life span study of atomic bomb survivors: 1958–2009, Radiat. Res., 2017, vol. 187, no. 5, pp. 513–537.

    Article  CAS  Google Scholar 

  7. Jangiam, W., Udomtanakunchai, C., Reungpatthanaphong, P., et al., Late effects of low-dose radiation on the bone marrow, lung, and testis collected from the same exposed BALB/cJ mice, Dose-Response, 2018, vol. 16, no. 4, pp. 1–13.

    Article  Google Scholar 

  8. Kataoka, T., Study of antioxidative effects and anti-inflammatory effects in mice due to low-dose X-irradiation or radiation, J. Radiat. Res., 2013, vol. 54, no. 4, pp. 587–596.

    Article  CAS  Google Scholar 

  9. Kojima, S., Nakayama, K., and Ishida, H., Low dose gamma-rays activate immune function via induction of glutathione and delay tumor growth, J. Radiat. Res., 2004, vol. 45, no. 1, pp. 33–39.

    Article  CAS  Google Scholar 

  10. Kojima, S., Tsukimoto, M., Shimura, N., et al., Treatment of cancer and inflammation with low-dose ionizing radiation: three case reports, Dose-Response, 2017, vol. 15, no. 1, pp. 1–7.

    Google Scholar 

  11. Large, M., Hehlgans, S., Reichert, U., et al., Study of the anti-inflammatory effects of low-dose radiation: the contribution of biphasic regulation of the antioxidative system in endothelial cells, Strahlenther. Onkol., 2015, vol. 191, pp. 742–749.

    Article  Google Scholar 

  12. Mikhailov, V.F., Shulenina, L.V., Vasilyeva, I.M., et al., The miRNA as human cell gene activity regulator after ionizing radiation, Russ. J. Genet., 2017, vol. 53, no. 3, pp. 285–296.

    Article  CAS  Google Scholar 

  13. Mikhailov, V.F., Shulenina, L.V., Raeva, N.F., et al., The effect of low doses of ionizing radiation on expression of genes and noncoding RNA in normal and malignant human cells, Cell Tissue Biol., 2019, vol. 13, no. 6, pp. 423–433.

    Article  Google Scholar 

  14. Nakatsukasa, H., Tsukimoto, M., Tokunaga, A., et al., Repeated gamma-ray irradiation attenuates collagen-induced arthritis via up-regulation of regulatory T cells, but not by damaging lymphocytes directly, Radiat. Res., 2010, vol. 174, no. 3, pp. 313–324.

    Article  CAS  Google Scholar 

  15. Premkumar, K. and Shankar, B.S., Involvement of MAPK signaling in radioadaptive response in BALB/c mice exposed to low dose ionizing radiation, Int. J. Radiat. Biol., 2016, vol. 92, no. 5, pp. 249–262.

    Article  CAS  Google Scholar 

  16. Shimura, N. and Kojima, S., The lowest radiation dose having molecular changes in the living body, Dose-Response, 2018, vol. 16, no. 2, pp. 1–7.

    Article  Google Scholar 

  17. Shulenina, L.V., Mikhailov, V.F., Raeva, N.F., et al., microRNA in the blood of prostate cancer patients as a possible indicator of development of early complications of radiotherapy, Radiats. Biol. Radioekol., 2017, vol. 57, no. 6, pp. 598–607.

    Google Scholar 

  18. Sutou, S., Black rain in Hiroshima: a critique to the Life Span Study of A-bomb survivors, basis of the linear no-threshold model, Genes Environ., 2020, vol. 42, no. 1, pp. 1–11.

    Article  CAS  Google Scholar 

  19. Timofeev-Resovskii, N.V., Biophysical interpretation of radiation stimulation of the plants, Biofizika (Moscow), 1956, vol. 1, no. 7, pp. 616–627.

    Google Scholar 

  20. Tsukimoto, M., Nakatsukasa, H., Sugawara, K., et al., Repeated 0.5-Gy γ-irradiation attenuates experimental autoimmune encephalomyelitis with up-regulation of regulatory T cells and suppression of IL-17 prodaction by Th17 cells, Radiat. Res., 2008, vol. 170, no. 4, pp. 429–436.

    Article  CAS  Google Scholar 

  21. Vaiserman, A., Koliada, A., and Socol, Y., Hormesis through low-dose radiation, in The Science of Hormesis in Health and Longevity, Rattan, S.I.S. and Kyriazis, M., Eds., London: Academic, 2019, pp. 129–138.

    Google Scholar 

  22. Vares, G., Wang, B., Ishii-Ohba, H., et al., Diet-induced obesity modulates epigenetic responses to ionizing radiation in mice, PLoS One, 2014, vol. 9, no. 8, p. e106277.

    Article  Google Scholar 

  23. Wang, B., Li, B., Dai, Z., et al., Low-dose splenic radiation inhibits liver tumor development of rats through functional changes in CD4+CD25+Treg cells, Int. J. Biochem. Cell Biol., 2014, vol. 55, pp. 98–108.

    Article  CAS  Google Scholar 

  24. Wouters, B. and Skarsgard, L., The response of a human tumor cell line to low radiation doses: evidence of enhanced sensitivity, Radiat. Res., 1994, vol. 138, no. 1, pp. 76–80.

    Article  Google Scholar 

  25. Yang, G., Yu, D., Li, W., et al., Distinct biological effects of low-dose radiation on normal and cancerous human lung cells are mediated by ATM signaling, Oncotarget, 2016a, vol. 7, no. 44, pp. 71856–71872.

    Article  Google Scholar 

  26. Yang, G., Li, W., Jiang, H., et al., Low-dose radiation may be a novel approach to enhance the effectiveness of cancer therapeutics, Int. J. Cancer, 2016b, vol. 139, pp. 2157–2168.

    Article  CAS  Google Scholar 

  27. Zasukhina, G.D., Adaptive response—biological trend: facts, hypothesis, and problems, Radiats. Biol. Radioekol., 2008, vol. 48, no. 4, pp. 464–473.

    CAS  Google Scholar 

  28. Zasukhina, G.D., Mechanisms of human cell resistance to mutagens, Biol. Bull. Rev., 2011, vol. 1, no. 6, pp. 496–508.

    Article  Google Scholar 

  29. Zhang, Y.-C., Jiang, G., Gao, H., et al., Influence of ionizing radiation on ovarian carcinoma SKOV-3 xenografts in nude mice under hypoxic conditions, Asian Pac. J. Cancer Prev., 2014, vol. 15, no. 5, pp. 2353–2358.

    Article  Google Scholar 

  30. Zhao, Y., Kong, C., Chen, X., et al., Repetitive exposure to low-dose X-irradiation attenuates testicular apoptosis in type 2 diabetic rats, likely via Akt-mediated Nrf2 activation, Mol. Cell Endocrinol., 2016, vol. 422, pp. 203–210.

    Article  CAS  Google Scholar 

  31. Zhou, L., Zhang, X., Li, H., et al., Validating the pivotal role of the immune system in low-dose radiation-induced tumor inhibition in Lewis lung cancer-bearing mice, Cancer Med., 2018, vol. 7, no. 4, pp. 1338–1348.

    Article  CAS  Google Scholar 

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Funding

This work was carried out according to theme of the Vavilov Institute of General Genetics, Russian Academy of Sciences (state assignment no. 0112-2019-0002) and was supported by the Program for the Development of Nuclear Medicine “AO Science and Innovation” of GK Rosatom.

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Correspondence to V. F. Mikhailov or G. D. Zasukhina.

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Conflict of interest. The authors declare that they have no conflict of interests.

Statement on animal welfare. This article does not contain any studies involving animals performed by any of the authors.

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Translated by E. Kuznetsova

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Mikhailov, V.F., Zasukhina, G.D. A New Approach to the Stimulation of the Body’s Defense Systems with Low Radiation Doses. Biol Bull Rev 10, 475–482 (2020). https://doi.org/10.1134/S2079086420060031

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  • DOI: https://doi.org/10.1134/S2079086420060031

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