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Safety and Efficacy of the Neuroform Atlas Stent for Treatment of Intracranial Aneurysms

A Systematic Review and Meta-Analysis

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Abstract

Objective

The Neuroform Atlas (Stryker Neurovascular, Fremont, CA, USA) is a low-profile laser cut self-expanding nitinol stent designed to provide coil support and wall apposition during aneurysm embolisation. In this study, we performed a meta-analysis of outcomes after treatment with the Neuroform Atlas stent for the purpose of coil embolisation.

Methods

The primary objectives of this meta-analysis were to define the safety (treatment-related complications, neurologic outcomes, mortality rate) and the efficacy (aneurysm occlusion rate) of the treatment of intracranial aneurysms with the Neuroform Atlas stent. A systematic review and meta-analysis was performed by searching PubMed, EMBASE, and the Cochrane CENTRAL Library for all published studies on the treatment of intracranial aneurysms with the Neuroform Atlas device up to 6 April 2020. The review was prepared in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Results

A total of 14 studies were analysed (577 patients with 593 intracranial aneurysms). The mean age was 58.2 years and 35.6% were male. Technical success of the procedure was 100%. RROC1/RROC2 (Raymond-Roy occlusion classification (RROC) 1/2) (total occlusion/neck remnant) at a mean follow-up of 8.9 months was achieved in 94.8%. RROC3 was 4.9%. All-cause mortality was 1.8% and permanent residual neurological deficit or disability was 2.7%. Overall complications at follow-up were 6.2%.

Conclusion

Our analysis demonstrated good rates of occlusion at follow-up for aneurysms treated with the Atlas device at follow-up. The safety profile appears similar to other low-profile intracranial stents.

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Funding

No funding was received for the performance of this meta-analysis.

Author information

Authors and Affiliations

  1. Neurointerventional Radiology, Essex Center for Neurological Sciences, Queen’s University Hospital, RM7 0AG, Romford, Greater London, UK

    Jeremy Lynch, Lakshmi Kanagarajah & Shahram Derakhshani

  2. Neuroradiology, King’s College Hospital, SE5 9RS, Denmark Hill, London, UK

    Sara Sciacca & Juveria Siddiqui

Authors
  1. Jeremy Lynch
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  2. Sara Sciacca
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  3. Juveria Siddiqui
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  4. Lakshmi Kanagarajah
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  5. Shahram Derakhshani
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Contributions

JL and SD design and conception of the work. JL, JS, and SS data collection. All authors: critical review and revision of the manuscript, interpretation of data.

Corresponding author

Correspondence to Jeremy Lynch.

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Conflict of interest

J. Lynch, S. Sciacca, J. Siddiqui and L. Kanagarajah declare that they have no competing interests. S. Derakhshani has worked as a consultant for Stryker Neurovascular.

Ethical standards

No novel patient data were obtained for this study. No human or animal studies were undertaken in this study.

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All collected data are included in the manuscript and accompanying tables.

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Lynch, J., Sciacca, S., Siddiqui, J. et al. Safety and Efficacy of the Neuroform Atlas Stent for Treatment of Intracranial Aneurysms. Clin Neuroradiol 31, 1167–1180 (2021). https://doi.org/10.1007/s00062-020-00979-y

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  • DOI: https://doi.org/10.1007/s00062-020-00979-y

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