Gold/Lewis acid catalyzed oxidative cyclization involving activation of nitriles

Ali Wang; Xin Xie; Chunli Zhang; Yuanhong Liu

doi:10.1039/D0CC06875F

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Gold/Lewis acid catalyzed oxidative cyclization involving activation of nitriles†

Ali Wang,^a Xin Xie,^a Chunli Zhang^a and Yuanhong Liu

*^a

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* Corresponding authors

^a State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
E-mail: yhliu@sioc.ac.cn

Abstract

A gold-catalyzed oxidative cyclization of alkyne–nitriles using water or alcohol as the external nucleophiles has been developed. The catalytic system, featured with gold and Lewis acid dual catalysis, allows a facile synthesis of functionalized isoquinolin-1(2H)-ones and 1-alkoxy-isoquinolines with a wide structural diversity.

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DOI: https://doi.org/10.1039/D0CC06875F
Article type: Communication
Submitted: 15 Oct 2020
Accepted: 16 Nov 2020
First published: 17 Nov 2020

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Chem. Commun., 2020,56, 15581-15584

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Gold/Lewis acid catalyzed oxidative cyclization involving activation of nitriles

A. Wang, X. Xie, C. Zhang and Y. Liu, Chem. Commun., 2020, 56, 15581 DOI: 10.1039/D0CC06875F

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Chemical Communications

Gold/Lewis acid catalyzed oxidative cyclization involving activation of nitriles†

Abstract

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Gold/Lewis acid catalyzed oxidative cyclization involving activation of nitriles

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