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Protein-Sorption and the Hemostatic Properties of Composite Materials Based on Polyurethane Foam Filled with Silicon and Aluminum Oxides

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Theoretical and Experimental Chemistry Aims and scope

An effective hemostatic composite material was obtained due to the combination of water-absorption, protein-sorption, and hemostatic properties of highly dispersed oxides of SiO2 and Al2O3 with the cellular structure of polyurethane foam. It was found that a sample with a silica content of 5 wt.% has the highest parameters of osmotic activity and water absorption. The protein-adsorption activity of the fillers in the composite is slightly reduced, but remains at a level sufficient for the manifestation of biological activity. The hemostatic effect of the composite materials was studied in a model of parenchymal bleeding in rats.

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Authors and Affiliations

  1. O. O. Chuiko Institute of Surface Chemistry, NAS of Ukraine, Kyiv, Ukraine

    A. A. Kravchenko, I. I. Gerashchenko, T. V. Krupska & N. V. Guzenko

  2. Institute of High Technologies, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine

    L. Ya. Shtanova, I. V. Komarov, P. I. Yanchuk, S. P. Veselskiy, O. V. Tsymbalyuk & V. M. Baban

  3. Taras Shevchenko National University of Kyiv, Kyiv, Ukraine

    L. Ya. Shtanova & T. V. Vovkun

  4. O. O. Bogomolets National Medical University, Kyiv, Ukraine

    O. V. Kravchenko

Authors
  1. A. A. Kravchenko
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  2. I. I. Gerashchenko
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  3. L. Ya. Shtanova
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  4. T. V. Krupska
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  5. N. V. Guzenko
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  6. O. V. Kravchenko
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  7. I. V. Komarov
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  8. P. I. Yanchuk
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  9. S. P. Veselskiy
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  10. O. V. Tsymbalyuk
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  11. T. V. Vovkun
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  12. V. M. Baban
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Corresponding author

Correspondence to A. A. Kravchenko.

Additional information

Translated from Teoretychna ta Eksperymentalna Khimiya, Vol. 56, No. 5, pp. 324-330, September-October, 2020.

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Kravchenko, A.A., Gerashchenko, I.I., Shtanova, L.Y. et al. Protein-Sorption and the Hemostatic Properties of Composite Materials Based on Polyurethane Foam Filled with Silicon and Aluminum Oxides. Theor Exp Chem 56, 352–358 (2020). https://doi.org/10.1007/s11237-020-09665-z

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  • DOI: https://doi.org/10.1007/s11237-020-09665-z

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