Issue 46, 2020
From the journal:

Nanoscale

Halloysite nanotubes – the nano-bio interface

Ofer Prinz Settera  and  Ester Segal ORCID logo *a  

* Corresponding authors

a Department of Biotechnology and Food Engineering, Technion – Israel Institute of Technology, Technion City, 3200003 Haifa, Israel
E-mail: esegal@technion.ac.il

Abstract

The numerous biological applications of nanoparticles in general and nano-clays in particular are rooted in understanding and harnessing their dynamic nano-bio interface. Among clays, the intrinsically-mesoporous halloysite nanotubes (HNTs) have emerged in recent years as promising nanomaterials. The diverse interactions of these nanotubes with living cells, encompassing electrostatic, van der Waals, and ion exchange, along with cellular response, are crucial in determining the behaviour of HNTs in biological systems. Thus, rational engineering of the nanotube properties allows for vast applications ranging from bacteria encapsulation for bioremediation, through algae flocculation for aquaculture, to intracellular drug delivery. This review summarizes the many aspects of the nano-bio interface of HNTs with different cell types (bacteria, algae and fungi, and mammalian cells), highlighting biocompatibility/bio-adverse properties, interaction mechanisms, and the latest cutting-edge technologies.

Graphical abstract: Halloysite nanotubes – the nano-bio interface

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Article information

DOI
https://doi.org/10.1039/D0NR06820A
Article type
Review Article
Submitted
26 Jul 2020
Accepted
20 Oct 2020
First published
25 Nov 2020
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2020,12, 23444-23460

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Halloysite nanotubes – the nano-bio interface

O. Prinz Setter and E. Segal, Nanoscale, 2020, 12, 23444 DOI: 10.1039/D0NR06820A

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