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Development of a Method for Determination of Related Impurities in GML-3 Drug Substance: A New Compound with Anxiolytic Properties

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Pharmaceutical Chemistry Journal Aims and scope

A method for determination of related impurities in the new anxiolytic drug substance GML-3 was developed. HPLC and TLC techniques that could identify starting materials and synthetic intermediates and quantify them and unidentified impurities with contents of 0.05% and less in the drug substance were developed. The proposed techniques could be used further for quality control of GML-3 drug substance.

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Authors and Affiliations

  1. V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, 125315, Russia

    L. N. Grushevskaya, M. S. Sergeeva, L. M. Gaevaya, M. E. Dudenkova, E. D. Denisenko, N. I. Avdyunina, S. V. Minaev & G. V. Mokrov

Authors
  1. L. N. Grushevskaya
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  2. M. S. Sergeeva
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  3. L. M. Gaevaya
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  4. M. E. Dudenkova
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  5. E. D. Denisenko
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  6. N. I. Avdyunina
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  7. S. V. Minaev
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  8. G. V. Mokrov
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Corresponding author

Correspondence to L. N. Grushevskaya.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 8, pp. 40 – 46, August, 2020.

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Grushevskaya, L.N., Sergeeva, M.S., Gaevaya, L.M. et al. Development of a Method for Determination of Related Impurities in GML-3 Drug Substance: A New Compound with Anxiolytic Properties. Pharm Chem J 54, 838–845 (2020). https://doi.org/10.1007/s11094-020-02284-x

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  • DOI: https://doi.org/10.1007/s11094-020-02284-x

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