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Design, Synthesis, Characterization, and Crystallographic Behaviors of Some Biologically Important Chromene-Annulated Spiro-Oxindoles: A Drive to Introspect the Comparative Structural Information

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Abstract

The compounds, 2-amino-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile (4a), 2-amino-1'-methyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile (4b), and 2-amino-1',7,7-trimethyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile (4c) were synthesized and characterized by elemental analyses, spectral studies (FT-IR, NMR, Mass) and single-crystal X-ray analysis. All the compounds crystallize in the monoclinic sp. gr. P21/c. In crystals of all three compounds, the molecules are linked by an elaborate system of N–H⋅⋅⋅O and N–H⋅⋅⋅N hydrogen bonds to form supramolecular structures.

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Funding

GB is thankful to the SERB-DST, New Delhi for financial support (Grant no. EMR/2014/001220).

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Authors and Affiliations

  1. Department of Physics, University of Jammu, 180 006, Jammu Tawi, India

    S. Sharma & V. K. Gupta

  2. Laboratory of Natural Products and Organic Synthesis, Department of Chemistry, Visva-Bharati (a Central University), 731 235, Santiniketan, West Bengal, India

    G. Brahmachari

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  1. S. Sharma
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  3. V. K. Gupta
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Correspondence to V. K. Gupta.

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Sharma, S., Brahmachari, G. & Gupta, V.K. Design, Synthesis, Characterization, and Crystallographic Behaviors of Some Biologically Important Chromene-Annulated Spiro-Oxindoles: A Drive to Introspect the Comparative Structural Information. Crystallogr. Rep. 65, 1179–1186 (2020). https://doi.org/10.1134/S1063774520070147

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  • DOI: https://doi.org/10.1134/S1063774520070147

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