Abstract
There has been a developing interest in the green-mediated synthesis of metal nanorods (NRs), especially from plants. However, there is no published report on the synthesis of ZnO NRs prepared via Cyrtrandroemia nicobarica leaf extract. The formation of ZnO NRs was confirmed by using x-ray diffraction, a Fourier transform infrared spectrometer, Brunauer–Emmett–Teller analysis, scanning electron microscope-energy-dispersive x-ray spectroscopy, and transmission electron microscopy analyses. The result revealed that the acquired ZnO NRs contain a unique surface area and excellent particle size. The photocatalytic and antioxidant activities of ZnO NRs were also evaluated in this study. The toxic nature of the obtained ZnO NRs was analyzed using the Daniorerio model, and the results showed that it was nontoxic. The anticancer activity of ZnO NRs was also analyzed using a human lung cancer cell line (A549), and excellent results were observed about the cancer cell death pathway. Hence, it was confirmed that the acquired ZnO NRs were nontoxic and had magnificent antibacterial and antioxidant activities. They can be used as an anticancer drug for health-care implementations.
Similar content being viewed by others
References
L.S. Rebecca, D.M.P. Kimberly, and D.V.M.A. Jemal, CA Cancer J. Clin. 121, 5 (2020).
W.J. Curran, R. Paulus, and C.J. Langer, J. Natl Cancer Inst. 103, 1460 (2011).
X. Li, P. Kabolizadeh, and D. Yan, Radiat. Oncol. 13, 35 (2018).
R. Sinha, G.J. Kim, and S. Nie, Mol. Cancer Ther. 5, 1917 (2006).
T. Mosmann, J. Immunol. Methods 65, 63 (1983).
T. Bhuyan, M. Khanuja, R. Sharma, S. Patel, M.R. Reddy, S. Anand, and A. Varma, J. Nanopart. Res. 17, 288 (2015).
M. Zare, K. Namratha, S. Alghamdi, Y.H.E. Mohammad, A. Hezam, M. Zare, Q.A. Drmosh, K. Byrappa, B.N. Chandrashekar, S. Ramakrishna, and X. Zhang, Sci. Rep. 9, 8303 (2019).
F.T. Thema, M. Elayaperumal, M. Maaza, and M.S. Dhlamini, Mater. Lett. 18, 287 (2015).
M. Shaalan, M. Saleh, M. El-Mahdy, and M. El-Matbouli, Nanomedicine 12, 710 (2016).
S.P. Mathew, J. Econ. Taxon. Bot. 22, 272 (1998).
L.J. Singh, C. Murugan and P. Singh, Int. J. Curr. Res. Biosci. Plant Biol. 23, 57 (2014).
V. Sekar, B. vaseeharan, B. Malaikozhundan, and M. Shobiya, Biomed. Pharmacother. 23, 84 (2016).
H.A. Kiwaan, T.M. Atwee, E.A. Azab, and A.A. El-Bindary, J. Mol. Struct. 1200, 127115 (2020).
A.A. El-Bindary, S.M. EI-Marsafy, and A.A. EI-Maddah, J. Mol. Struct. 1194, 84 (2019).
G. Karunakaran, M. Jagathambal, N.V. Minh, E. Kolesnikov, and D. Kuznetsov, JOM 70, 1343 (2018).
R. Suriyaprabha and V. Rajendran, Artif. Cells Nanomed Biotechnol. 46, 1424 (2018).
G. Karunakaran, M. Jagathambal, A. Gusev, E. Kolesnikov, A.R. Mandal, and D. Kuznetsov, JOM 6, 46 (2016).
G. Karunakaran, M. Jagathambal, A. Gusev, E. Kolesnikov, A.R. Mandal, and D. Kuznetsov, Powder Technol. 305, 494 (2017).
N. Siti, M.S. Amalina, S. Kamyar, T. Wong, S.Y. Teow, J. Chew, and N.A. Ismail, J. Mol. Struct. 1189, 65 (2019).
R. Anitha, K.V. Ramesh, T.N. Ravishankar, K.H. Sudheer Kumar, and T. Ramakrishnappa, Adv. Mater. Devices 3, 451 (2018).
V. Shah, B. Bharatiya, M. Mishra, D. Ray, and D. Shah, J. Mol. Liq. 273, 222–230 (2019).
G. Karunakaran, R. Suriyaprabha, P. Manivasakan, R. Yuvakkumar, V. Rajendran, and N. Kannan, Ecotoxicol. Environ. Saf. 93, 197 (2013).
M. Ovais, A.T. Khalil, A. Raza, M.A. Khan, I. Ahmad, U. Nazar, S. Saravanan, M. Ubaid, M. Ali, and Z.K. Shinwari, Int. J. Pharm. Chem. Biol. Sci. 4, 111 (2014).
T.P. Dasari, K. Pathakoti, and H.M. Hwang, J. Environ. Sci. 25, 888 (2013).
M. Stępnik, J. Arkusz, P.A. Smok, A. Bratek-Skicki, A. Salvati, L.I. Lynch, A. Kenneth, M. Dawson, J. Gromadzińska, H. Wim, D. Jong, and K. Rydzyński, Toxicol. Appl. Pharmacol. 263, 101 (2012).
T. Bhuyan, K. Mishra, M. Khanuja, R. Prasad, and A. Varma, Mat. Sci. Semicon. Proc. 32, 55 (2015).
A. Moawad, M. Hetta, J.K. Zjawiony, M.R. Jacob, M. Hifnawy, J.P. Marais, and D. Ferreira, Planta Med. 76, 802 (2010).
E. Karakose and H. Çolak, Energ. J. 140, 92 (2017).
P. Vishnukumar, S. Vivekanandhan, and S.M. Misra, Mat. Sci. Semicon. Proc. 80, 143 (2018).
S. Alarifi, D. Ali, S. Alkahtani, and M.S. Alhader, Biol. Trace Elem. Res. 159, 424 (2014).
A. Lak, M. Mazloumi, M.S. Mohajerani, S. Zanganeh, M.R. Shayegh, A. Kajbafvala, and H. Arami, J. Am. Ceram. Soc. 91, 3584 (2008).
R. Vani, S.B. Raja, T.S. Sridevi, K. Savithri, S.N. Devaraj, E.K. Girija, A. Thamizhavel, and S.N. Kalkura, Nanotechnology 22, 285701 (2011).
A.A. Khan, A. Vladimir, and A. Fonoberov, J. Appl. Phys. 97, 313 (2005).
H. Liu, L. Zhong, S. Govindaraj, and K. Yuna, J. Phys. Chem. Solids 129, 53 (2019).
B. Sonik and V. Neha, Mater. Res. Bull. 95, 476 (2017).
K.W. Ng, S.P.K. Khoo, B.C. Heng, M.I. Setyawati, E.C. Tan, X. Zhao, S. Xiong, W. Fang, D.T. Leong, and J.S.C. Loo, Biomaterials 32, 8225 (2011).
D. Xiong, T. Fang, L. Yu, X. Sima, and W. Zhu, Sci. Total Environ. 409, 1452 (2011).
G.S. Kumar, E.K. Girija, M. Venkatesh, G. Karunakaran, E. Kolesnikov, and D. Kuznetsov, Ceram. Int. 43, 3461 (2017).
G.S. Kumar, S. Rajendran, S. Karthi, R. Govindan, E.K. Girija, G. Karunakaran, and D. Kuznetsov, MRS. Commun. 7, 188 (2017).
J. Liu, K. Li, H. Wang, M. Zhu, and H. Yan, Chem. Phys. Lett. 396, 432 (2004).
G. Karunakaran, M. Jagathambal, A. Gusev, N.V. Minh, E. Kolesnikov, A.R. Mandal, and D. Kuznetsov, IET Nanobiotechnol. 10, 425 (2016).
Acknowledgements
The authors thank the management of K. S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode, Tamil Nadu, for their support and encouragement.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors report no conflicts of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic Supplementary Material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Sudha, K.G., Ali, S., Karunakaran, G. et al. Cyrtrandroemia nicobarica-Synthesized ZnO NRs: A New Tool in Cancer Treatment. JOM 73, 364–372 (2021). https://doi.org/10.1007/s11837-020-04486-w
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11837-020-04486-w