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Does Weight Loss Improve Clinical Outcomes in Overweight and Obese Patients with Heart Failure?

  • Obesity (KM Gadde and P Singh, Section Editors)
  • Published:
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Abstract

Purpose of Review

Obesity increases the risk of new onset heart failure (HF), and particularly HF with preserved ejection fraction (HFpEF). Despite the observations of favorable clinical outcomes in HF patients with obesity in general, sometimes referred to as the “obesity paradox,” it is important to recognize that severe obesity is associated with worse clinical outcomes. This review summarizes the effects of obesity treatment on cardiovascular health and HF clinical outcomes.

Recent Findings

Treatment for obesity utilizes a variety of modalities to achieve purposeful weight loss including lifestyle intervention, medications, and bariatric surgery. There are a cluster of benefits of obesity treatment in terms of clinical outcomes in HF. The mechanisms of these benefits include both weight loss-dependent and weight loss-independent mechanisms.

Summary

Obesity treatment is safe and associated with favorable clinical outcomes across the spectrum of the HF population. The potential benefits are facilitated through multiple mechanisms.

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Funding

Dr. Tang is partially supported by grants from the National Institutes of Health and the Office of Dietary Supplements (R01HL103931, R01DK106000, R01HL126827).

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  1. Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Kaufman Center for Heart Failure Treatment and Recovery, Cleveland Clinic, 9500 Euclid Avenue, Desk J3-4, Cleveland, OH, 44195, USA

    Thida Tabucanon & W. H. Wilson Tang

  2. Thammasat Heart Center, Thammasat University Hospital, Khlong Luang, Pathum Thani, Thailand

    Thida Tabucanon

  3. Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA

    Jennifer Wilcox & W. H. Wilson Tang

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Thida Tabucanon and Jennifer Wilcox each declare no potential conflicts of interest. W. H. Wilson Tang is a consultant for Sequna Medical A.G. and Owkin Inc, and has received honorarium from Springer Nature for authorship/editorship, all unrelated to the contents of this paper.

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Tabucanon, T., Wilcox, J. & Tang, W.H.W. Does Weight Loss Improve Clinical Outcomes in Overweight and Obese Patients with Heart Failure?. Curr Diab Rep 20, 75 (2020). https://doi.org/10.1007/s11892-020-01367-z

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