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Effect of Tussilago farfara L. Polysaccharides on the Content of Hematopoietic Stem Cells (CD117+34+) in the Bone Marrow of Mice Treated with Cyclophosphamide

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Bulletin of Experimental Biology and Medicine Aims and scope

Myelotoxicity is a serious side effect of anticancer drugs. The search for drugs that can reduce the hematological complications of chemotherapy through modulation of hematopoietic stem cells is an urgent task of oncopharmacology. In the present study we showed that administration of Tussilago farfara L. polysaccharides to C57BL/6 mice treated with cyclophosphamide can increase the number of hematopoietic stem cells (CD117+34+) in the bone marrow.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    E. A. Safonova, K. A. Lopatina, T. G. Razina, S. G. Krylova & E. P. Zueva

  2. Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    A. R. Dyagel, A. M. Gur’ev & M. V. Belousov

Authors
  1. E. A. Safonova
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  2. K. A. Lopatina
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  3. A. R. Dyagel
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  4. T. G. Razina
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  5. S. G. Krylova
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  6. A. M. Gur’ev
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  7. M. V. Belousov
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  8. E. P. Zueva
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Corresponding author

Correspondence to E. A. Safonova.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 3, pp. 217-220, September, 2020

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Safonova, E.A., Lopatina, K.A., Dyagel, A.R. et al. Effect of Tussilago farfara L. Polysaccharides on the Content of Hematopoietic Stem Cells (CD117+34+) in the Bone Marrow of Mice Treated with Cyclophosphamide. Bull Exp Biol Med 170, 171–174 (2020). https://doi.org/10.1007/s10517-020-05025-y

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  • DOI: https://doi.org/10.1007/s10517-020-05025-y

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