Developmental Cell
Volume 55, Issue 4, 23 November 2020, Pages 381-382
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Addicted to Acidic Microenvironment

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Acidic pH levels are often observed in growing tumors, with profound effects on cancer cells and surrounding microenvironment. In this issue of Developmental Cell, Funato et al. (2020) show that expression of oncogenic phosphatase of regenerating liver 3 (PRL3) shifts cellular preference for environmental pH, leading to acid addiction.

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